The central nervous system (CNS) of terrestrial vertebrates underwent a prominent molecular change when proteolipid protein (PLP) replaced P0 protein as the most abundant protein of …

Here we show that the abundance of PLP but not of other tetraspan myelin proteins is strongly increased in compact peripheral myelin of P0 (null)-mice. To determine the functional …

PLP is a 30-kDa integral membrane protein mainly expressed by CNS oligodendrocytes. Minor expression can be observed in PNS myelin, as well as in kidney distal and proximal tubules . …

1997年7月1日 · The intriguing phylogenetic analyses of P0, DM20, and PLP by Yoshida and Colman 1996 demonstrate that PLP/DM20 is present in PNS compact myelin of teleosts and …

To investigate the possible consequences of a PLP to P 0 shift in PNS myelin, we engineered mice to express PLP instead of P 0 in PNS myelin (PLP-PNS mice). PLP-PNS mice had …

Steady-state levels of PLP mRNA in SC cultures treated with the cAMP analogue dibutyryl cAMP (dBcAMP) were not increased, whereas dBcAMP increased steady-state levels of mRNA …

2014年7月28日 · The central nervous system (CNS) of terrestrial vertebrates underwent a prominent molecular change when proteolipid protein (PLP) replaced P 0 protein as the most …

2025年2月8日 · axonal mitochondria, smooth endoplasmic reticulum, and microtubules were characterized in rodent optic nerves where PLP is replaced by the peripheral nerve myelin …

Concomitant expression of proteolipid protein (PLP) and P0 in remyelinating cerebral lesion (index case 1). (A) The peripheral nerve from case 4 was stained with an antibody to P0 (green) and …

PLLP is involved in intracellular transport, lipid raft formation, and Notch signaling. PLLP is presumably involved in various disorders, such as cancer, schizophrenia, Alzheimer’s disease, …