PML is most likely to be found in patients with lymphoproliferative and myeloproliferative diseases, solid organ malignancies, HIV (human immunodeficiency virus) infection, autoimmune diseases, and in patients on antirejection immunosuppressive drugs after organ transplantation or patients treated with immunomodulatory therapies such as ...

2022年10月19日 · Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the central nervous system (CNS), caused by the human polyoma virus JC virus (JCV) and characterized by focal demyelination. 1,2 JCV has a worldwide distribution, and 20% to 70% of people exhibit serologic evidence of exposure by their late teens or as adults. 3-7 ...

PML typically only occurs in people who have severely weakened immune systems. You may be at risk of developing PML if you have: HIV/AIDS. Leukemia (cancer in blood and bone marrow). Lymphoma (cancer in the lymph system). A donor organ and have taken immunosuppressant medicines (drugs to keep your body from rejecting the organ).

PML, which appeared in as many as 5% of HIV-positive individuals during the AIDS pandemic, is closely linked to HIV infection. HIV and JCV co-infection may have a synergistic effect that helps to explain this connection [7].

We report a case of JCV archetype-like variants-PML occurring in an HIV patient, shortly after a rescue HAART initiation which resulted in a persistent undetectable HIV viral load.

2019年12月27日 · There is no specific treatment for PML, but HIV therapy can reverse the symptoms and keep the JC virus under control. People with PML should have a good support system. Friends, roommates, or family members can help make sure that HIV medications are taken on time, in the right combination, and at the right dose.

Progressive multifocal leukoencephalopathy (PML) caused by the polyomavirus, JC virus (JCV), is one of the most dreaded complications of HIV-1 infection. Unlike other opportunistic infections, PML may present while blood CD4+ T cells remain above ...

2022年7月4日 · Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS characterized by widespread lesions due to infection of oligodendrocytes by...

2023年9月13日 · Progressive multifocal leukoencephalopathy (PML), a viral infection of the central nervous system (CNS), is most commonly associated with advanced HIV infection.

Progressive multifocal leukoencephalopathy is a rare infection that damages the material (myelin) that covers and protects nerves in the white matter of the brain. Learn more about PML and HIV with the following resources.