Progressive multifocal leukoencephalopathy (PML) is a rare, often fatal demyelinating disease of the central nervous system that occurs almost exclusively in immunosuppressed individuals. This disease is caused by the polyomavirus JC (JCV).

Oct 19, 2022 · Guidance for the prevention and treatment of progressive multifocal leukoencephalopathy (PML) caused by the JC virus in adults and adolescents with HIV.

Progressive multifocal leukoencephalopathy (PML) is a brain infection. It primarily affects people with weak immune systems, including HIV infection.

Although the severe neurological conditions - PML and progressive multifocal leukoencephalopathy immune reconstitution inflammatory syndrome (PML-IRIS) - are linked to HIV, little is known about their characteristics in the era of established antiretroviral therapy (ART).

Dec 27, 2019 · A description of progressive multifocal leukoencephalopathy (PML) and its symptoms (part of the Just Diagnosed program), from the VA National HIV website.

John Cunningham virus (JCV), the etiological agent of progressive multifocal leukoencephalopathy (PML), contains a hyper-variable non-coding control region usually detected in urine of healthy individuals as archetype form and in the brain and ...

Mar 31, 2025 · Progressive multifocal leukoencephalopathy (PML) is a severe viral infection of the central nervous system, primarily affecting individuals with severe immunosuppression due to conditions...

PML is a rare manifestation of JCV reactivation and characteristically manifests as a complication of HIV-1 infection and other immunocompromising diseases or therapies.13-16 In recent years, PML has been reported in patients treated with immunomodulatory humanized antibodies, including natalizumab17 and efalizumab.18 Concern has been raised abo...

Progressive multifocal leukoencephalopathy is a rare infection that damages the material (myelin) that covers and protects nerves in the white matter of the brain. Learn more about PML and HIV with the following resources.

Progressive multifocal leukoencephalopathy (PML) caused by the polyomavirus, JC virus (JCV), is one of the most dreaded complications of HIV-1 infection. Unlike other opportunistic infections, PML may present while blood CD4+ T cells remain above ...