2024年12月25日 · PON1 (Paraoxonase 1) is a Protein Coding gene. Diseases associated with PON1 include Microvascular Complications Of Diabetes 5 and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7. Among its related pathways …

Paraoxonase 1 (PON1) also known as Serum paraoxonase and arylesterase 1, A esterase, homocysteine thiolactonase or serum aryldialkylphosphatase 1, is an enzyme that in humans is encoded by the PON1 gene. [5]

Human serum paraoxonase-1 (PON1) is a Ca 2+ dependent high-density lipoprotein (HDL) associated lactonase capable of hydrolysing a wide variety of lactones (including a number of pharmaceutical agents), thiolactones, arylesters, cyclic carbonates and organophosphate pesticides, nerve gases such as sarin and soman, glucuronide drugs and oestrogen...

Human serum paraoxonase-1 (PON1) is a calcium-dependent hydrolytic enzyme that is found in a variety of mammalian species. Abraham Mazur 1 and Norman Aldridge 2 played a pivotal role in the identification and classification of PON1 in the mid-1940s to early 1950s.

2016年5月2日 · Paraoxonases (PON1) are a family of enzymes involved in breaking down chemicals including several types of pesticides and pharmaceutical drugs. They are involved in protecting both high and low-density lipoproteins from oxidation, an important mechanism in atherosclerosis and heart disease.

2015年8月1日 · Human PON1 is a HDL-associated lipolactonase capable of preventing LDL and cell membrane oxidation and is therefore considered to be atheroprotective. PON1 contributes to the antioxidative function of HDL and reductions in HDL-PON1 activity, prevalent in a wide variety of diseases with an inflammato …

2024年12月10日 · Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017] Go to reference sequence details. Go to nucleotide: Graphics FASTA GenBank.

To better understand molecular mechanisms affecting gene expression, we used the candidate susceptibility gene paraoxonase 1 (PON1) as a model to assess associations of PON1 genetic polymorphisms with DNA methylation and arylesterase activity, a marker of PON1 expression.

This gene encodes a member of the paraoxonase family of Enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the Enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of ...

Gene ID: 5444, updated on 8-Feb-2025. This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity.