Covalent Modification of DNA Regulates Memory Formation
2007年3月15日 · Simultaneously, DNMTs target negative regulators of memory, such as PP1, for transcriptional silencing. DNMT activation results in increased methylation of the PP1 gene, …
DNMT inhibition prevents the PP1 methylation increase, resulting in aberrant transcription of the gene during the memory-consolidation period. These results demonstrate that DNA …
Dnmt1 and Dnmt3a are required for the maintenance of DNA …
In this study, we compared the phenotypes of conditional mutant mice deficient for either Dnmt1 or Dnmt3a (or both) exclusively in the forebrain postnatal postmitotic neurons. We aim to …
Dnmt1 and Dnmt3a maintain DNA methylation and regulate …
2010年3月14日 · We generated conditional mutant mice that lack Dnmt1, Dnmt3a or both exclusively in forebrain excitatory neurons and found that only double knockout (DKO) mice …
Memory and neuromodulation: A perspective of DNA …
2020年4月1日 · Another study detected increased levels of methylated PP1 along with mRNA downregulation in the hippocampus after contextual fear training (Miller and Sweatt, 2007). …
Neuronal DNA Methyltransferases: Epigenetic Mediators between …
2017年5月17日 · DNMT3A and 3B are the main de novo DNA methyltransferases (DNMTs) in the brain that introduce new methylation marks to non-methylated DNA in postmitotic neurons. …
The effect of hypoxia preconditioning on DNA methyltransferase …
Protein phosphatase 1 (PP1)γ, which critically regulates neuroprotective pathways in brain, was measured in mRNA and protein activity and promoter methylation. DNMT1 was unchanged in …
Covalent Modification of DNA Regulates Memory Formation
2007年3月15日 · DNMT inhibition prevents the PP1 methylation increase, resulting in aberrant transcription of the gene during the memory-consolidation period. These results demonstrate …
Macrophage DNMT1 aggravates proinflammatory cytokine …
Using a gene microarray analysis, we demonstrated that the DNMT1 transgene had a profound influence on the inflammatory pathways and the PPAR signaling pathway in the macrophages …
Covalent modification of DNA regulates memory formation
2007年3月15日 · DNMT inhibition prevents the PP1 methylation increase, resulting in aberrant transcription of the gene during the memory-consolidation period. These results demonstrate …