Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone reverse insulin resistance receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor functioning as a transcription factor that in humans is encoded by the PPARG gene.

PPAR gamma靶点介绍 蛋白功能 结合过氧化物酶体增殖物，如降血脂药物和脂肪酸的核受体。一旦被配体激活，核受体与DNA特异性PPAR反应元件（PPRE）结合，并调节其靶基因的转录，如酰基辅酶a氧化酶。因此，它控制着脂肪酸的过氧化物酶体-氧化途径。

2024年12月25日 · Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.

2013年5月7日 · Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral...

Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-modulated transcription factor that governs the expression of genes involved in inflammation, redox equilibrium, trophic factor production, insulin sensitivity, and the metabolism of lipids and glucose.

过氧化物酶体增殖物激活受体（peroxisome proliferators-activated receptors，PPARs）是核激素受体家族中的配体激活受体，在不同的物种中已经发现了它的3种亚型，控制许多细胞内的代谢过程，属于配体诱导核受体（ligand-inducible nuclear receptors）。

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis.

过氧化物酶体增殖物活化受体γ （Peroxisome proliferator-activated receptor gamma ，缩写为 PPAR-γ 或 PPARG），也称胰島素增敏劑受体（glitazone receptor），或 NR1C3 （意为核受体第一亚科C集团第3号，nuclear receptor subfamily 1, group C, member 3）是一种位于人类染色体上的二型核受体，由PPARG 基因 编码。 [2][3][4] 对 脂肪细胞 和 胰岛素 有重要的作用，是治疗 糖尿病 的研究对象之一。 [5]

2021年1月15日 · Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that regulate the expression of genes related to lipid and glucose metabolism and inflammation. There are three members: PPARα, PPARβ or PPARγ. PPARγ have several ligands. The natural agonists are omega 9, curcumin, eicosanoids and others.

Peroxisome proliferator-activated receptor gamma (PPARγ) has been the focus of intense research because ligands for this receptor have emerged as potent insulin sensitizers used in the treatment of type 2 diabetes. There have been described three PPAR isotypes α, δ and γ which have an integrated rol …