PPARγ as an E3 Ubiquitin-Ligase Impedes Phosphate-Stat6 ... - PubMed
2020年6月19日 · Biochemical analyses indicated that inhibitory effect of EP4 signal on IgE depended on the activation of the PI3K-AKT pathway. Further downstream, PPARγ …
The Role of PPAR-γ in Allergic Disease | Current Allergy ... - Springer
2021年10月25日 · PPAR-γ has been found to promote the functions of TH2 cells, type 2 innate lymphoid cells, M2 macrophages and dendritic cells, regulating lipid metabolism and directly …
The Role of PPAR-γ in Allergic Disease - PMC - PubMed Central …
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a nuclear receptor that has emerged as an important regulator of multiple cell types involved in the inflammatory response to allergens; …
Peroxisome Proliferator–activated Receptors α and γ Down …
Allergic asthma is characterized by airway hyperresponsiveness, eosinophilia, and mucus accumulation and is associated with increased IgE concentrations. We demonstrate here that …
Inhibition effect of PPAR-γ signaling on mast cell-mediated …
2022年7月1日 · Our data showed that activated PPAR-γ has the potential to alleviate food allergies by enhancing intestinal mucosal integrity and tight junctions. Moreover, we found that …
PPARγ as an E3 Ubiquitin-Ligase Impedes Phosphate-Stat6 …
Yuhan Gao and his colleagues demonstrated that PGE 2 promotes IgE class switching, and the secretion of IgE by B cells stimulated in vitro with LPS+IL4 in an EP2-dependent manner . …
IL-4、PPAR-γ表达与过敏性鼻炎疾病活动度的相关性分析
2021年12月1日 · 摘要： 目的:检测白细胞介素4(il-4)、过氧化物酶体增殖物激活受体γ(ppar-γ)在过敏性鼻炎患者血清中的表达水平,并分析二者与过敏性鼻炎疾病活动度的相关性.方法:选取2018 …
Suppressive role of PPARγ in the IgE-dependent activation of
2020年2月7日 · Oral administration of pioglitazone (PPARγ agonist) significantly suppressed body temperature change of mice in passive systemic anaphylaxis, supporting the inhibitory …
S100A4 通过 RAGE 和 PPAR-γ 信号通路重新分析肥大细胞中的脂 …
相关性分析显示血清 S100A4 与血清 IgE 呈正相关，表明与哮喘存在间接关联。 总的来说，我们的研究结果表明，S100A4 可能通过 RAGE 和 PPAR γ 参与的信号通路调节肥大细胞的脂质代 …
Peroxisome proliferator-activated receptors alpha and gamma …
2003年8月4日 · Allergic asthma is characterized by airway hyperresponsiveness, eosinophilia, and mucus accumulation and is associated with increased IgE concentrations. We …