Molecular Actions of PPARα in Lipid Metabolism and Inflammation
2018年10月1日 · Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. PPARα also exhibits marked …
PPARα: An emerging target of metabolic syndrome, …
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that is involved in lipid metabolism of various tissues. Different metabolites of fatty acids and …
PPARγ signaling and metabolism: the good, the bad and the future
2013年5月7日 · Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective …
PPAR control of metabolism and cardiovascular functions
2021年6月14日 · PPARs are lipid sensors that modulate whole-body energy metabolism. PPARα promotes the adaptive response to fasting by controlling fatty acid transport, fatty acid …
Regulation of lipid and lipoprotein metabolism by PPAR activators
PPARalpha is considered a major regulator of intra- and extracellular lipid metabolism. Upon fibrate activation, PPARalpha down-regulates hepatic apolipoprotein C-III and increases …
Molecular mechanism of PPARα action and its impact on lipid …
2015年3月1日 · In this review, novel mechanistic insights into PPARα action, in hepatic lipid metabolism, under different nutritional states, and its role in liver inflammation and fibrosis are …
Molecular mechanism of PPARα action and its impact on lipid ... - PubMed
In this review, we discuss the transcriptional activation and repression mechanisms by PPARα, the spectrum of target genes and chromatin-binding maps from recent genome-wide studies, …
PPARs: Fatty acid sensors controlling metabolism
2012年8月1日 · The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key roles in the regulation of lipid metabolism, inflammation, cellular growth, and …
Molecular Actions of PPARα in Lipid Metabolism and Inflammation
2018年7月17日 · PPAR α controls the expression of numerous genes involved in a plethora of lipid metabolic pathways, including microsomal, peroxisomal, and mitochondrial FA oxidation …
PPARs and lipid ligands in inflammation and metabolism - PMC
PPARs mediate transcriptional activation and repression of gene expression. Multiple molecular mechanisms contribute to the modulation of PPAR activity in a given cell type that regulate …