Appropriate indications for PPI use include Helicobacter pylori infection, erosive esophagitis, gastric ulcers, and stress ulcer prevention in high-risk critically ill patients. Unfortunately, PPIs are often used off-label for extended periods of time.

Proton pump inhibitors (PPIs) are a group of medicines that decrease stomach acid production. They can help relieve symptoms of chronic acid reflux (GERD) and stomach ulcers. PPIs are available both over the counter and by prescription. Brands include Nexium, Prevacid and …

The purpose of this review is to evaluate the risks associated with long-term use of proton pump inhibitors (PPIs), focusing on long-term use of PPIs for three common indications: gastroesophageal reflux disease (GERD), Barrett’s esophagus (BE), and non-steroidal anti-inflammatory drug (NSAID) bleeding prophylaxis.

However, widespread PPI use has led to emerging evidence of long-term adverse effects not described previously, including increased risk of kidney, liver, and cardiovascular disease, dementia, enteroendocrine tumors of the gastrointestinal tract, susceptibility to respiratory and gastrointestinal infections, and impaired absorption of nutrients.

2018年2月1日 · Although PPIs have had an encouraging safety profile, recent studies regarding the long-term use of PPI medications have noted potential adverse effects, including risk of fractures, pneumonia, Clostridium difficile diarrhea, hypomagnesemia, vitamin B 12 deficiency, chronic kidney disease, and dementia.

2024年10月11日 · PPIs are considered safe for short-term use, but risks from longer-term use have been raised in numerous observational studies. Some of the concerns associated with long-term use include a higher risk of fracture because of interference with calcium absorption, an increased risk of certain infections (including pneumonia and C. difficile), and ...

2013年12月18日 · The long-term consequences of chronic PPI use include the potential increased risk of hypocalcemia, hypomagnesemia, Clostridium difficile infections, and pneumonia. Community pharmacists are poised to provide evidence-based recommendations and educate patients about the benefits and risks associated with chronic PPI use.

2017年9月20日 · This Review provides an update on the complications and risks of PPI use. Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-acid-related diseases.

However, many reports have emerged in the literature exposing the potential association of PPIs with various risks and complications such as bone fracture, infection, myocardial infarction, renal disease, and dementia.

2024年10月28日 · Proton pump inhibitors (PPI) are widely used medications for gastrointestinal disorders. Recent research suggests a potential association between long-term PPI use and increased cardiovascular (CV) risk, creating a complex clinical dilemma.