我们用CRISPR-Cas9技术成功构建了三个独立的PR1敲除突变体（pr1-1，pr1-2，pr1-3）。SA诱导基因PR1的突变相较与野生型，表现出正常的初生根（图3G）和数量增多的萌发侧根（图3H）。pr2-1 (GK800E10) 而不是pr2-2 (Salk_087824)突变体与野生型相比具有稍长的主 …

2021年11月1日 · SA induces the hypersensitive response and systemic acquired resistance (SAR). It involves multifaceted network of the SA receptor Non-Expressor of Pathogenesis Related protein-1, reactive oxygen species, calcium ions, nitric oxide and mitogen-activated protein kinase cascades.

2020年8月12日 · Previous genetic studies of SA-insensitive mutants in A. thaliana have identified NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) as a transcriptional coactivator that is indispensable for...

2023年3月17日 · However, only PR1 is transcriptionally induced upon pathogen attack. Expression of PR1 is controlled by the stress hormone salicylic acid (SA), and the rate of PR1 transcription is frequently used to monitor SA-induced immune pathways and systemic acquired resistance (SAR) (Vlot et al., 2009).

2015年6月12日 · Salicylic acid (SA) is an immune signal that increases in response to pathogen infection 26, and this increase often coincides with elevated expression of antimicrobial...

2024年3月1日 · Elevated SA level triggers SAR by coordinated activation of PR genes (e.g. PR1, PR2, PR5) and involves one or more long-distance signals that transmit an augmented immune signal to distal healthy non-infected plant parts (Fu and Dong, 2013).

2022年1月15日 · In the first layer, cell surface-localized pattern-recognition receptors (PRRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and then elicit PAMP-triggered immunity (PTI).

该研究发现，NPR1在SA作用下形成NPR1凝聚体 (salicylic acid-induced NPR1 condensates, SINCs)。 SINCs富含应激响应蛋白，包括NB-NLR类蛋白受体、氧化和DNA损伤响应蛋白、泛素化相关蛋白等。

1999年8月1日 · The relationship between salicylic acid (SA) accumulation, PR-1 gene expression, and the degree of systemic acquired resistance (SAR) established in Arabidopsis plants has been determined by comparing the response of wild-type ecotype Columbia (Col-0) and two hypersensitive response (HR)-defective mutants (rps2-201 andrps2-101C) during the SAR ...

2020年10月13日 · 该研究发现，npr1和npr3/4可以通过调控nhp合成相关基因ald1，sard4及fmo1的表达控制nhp的积累，从而影响sar。此外，病原体模式分子引发的pti和效应分子引发的eti在npr1-1 npr4-4d突变体中也大幅度减弱，表明sa受体在调控pti和eti方面也有重要贡献。