
(三)Rb/E2F 途径在细胞周期调控中的作用 - KKME
PRb 的磷酸化能够使pRb 脱离E2F/DP 复合物,从而启动基因的激活。 CyclinD1/CDK4 蛋白复合物能够在细胞周期进入S 前对pRb 进行磷酸化,而这个复合物有能受到肿瘤抑癌基因INK4a …
癌症中的E2F转录因子家族 - 知乎 - 知乎专栏
细胞周期蛋白依赖性激酶 (CDK)-RB-E2F 调控轴组成了驱动细胞周期进程、决定基因组复制的时间和准确性、并确保遗传物质准确传递的核心转录机制。 该调控轴的最终效应子是编码转录激 …
Clin Cancer Res:人类恶性肿瘤中pRB丢失的相关性 - 专区 - 生物谷
2021年9月13日 · 众所周知, pRB 通过抑制 E2F 转录因子的活性,发挥调节细胞周期进程的功能。 简言之, pRB 的功能直接受周期蛋白依赖性激酶 4 和 6 (CDK4/6) 和周期蛋白 D 复合物的 …
Modulation of pRB/E2F functions in the regulation of cell
The review focuses on the following topics: (i) how E2F and other substrates bind to pRb at the molecular level; (ii) mechanisms by which pRb function is modulated within the cell; (iii) …
pRB Contains an E2F1-Specific Binding Domain that Allows E2F1 …
2002年8月21日 · The interaction between pRB and E2F is critical for control of the cell cycle and apoptosis. Here we report that pRB contains two distinct E2F binding sites. The previously …
Conserved functions of the pRB and E2F families - Nature
In Drosophila melanogaster, RBF and dE2F proteins are key regulators of cell proliferation. E2F-protein control results from the functional interplay between activator and repressor complexes....
E2F-RB-p53 通路在肿瘤抑制中的扩展作用,Biology - X-MOL
源自生长刺激和生长抑制信号的信号通路汇聚到 prb(rb 通路)上以调节 e2f 活性。在大多数癌症中,prb的功能受到致癌突变的损害,e2f活性增强,从而促进细胞增殖,促进肿瘤发生。
Molecular mechanisms of E2F-dependent activation and pRB
2004年5月1日 · E2F has traditionally been viewed in the context of cell-cycle control. However, several recent studies have revealed a new aspect of E2F function in which pRB/E2F-family …
pRb-E2F signaling in life of mesenchymal stem cells: Cell ... - PubMed
2014年9月30日 · Through facultative and constitutive chromatin modifications, pRb-E2F signaling promotes transient and stable cells quiescence, cell fate choice to differentiate, to senesce, or …
RB and cell cycle progression | Oncogene - Nature
2006年8月28日 · The pRb protein represses gene transcription, required for transition from G1 to S phase, by directly binding to the transactivation domain of E2F and by binding to the …