Protein Regulator of cytokinesis 1 (PRC1) is a protein that in humans is encoded by the PRC1 gene and is involved in cytokinesis. [5][6] PRC1 protein is expressed at relatively high levels during S and G2/M phases of the cell cycle before dropping dramatically after mitotic exit and entrance into G1 phase.

Polycomb repressive complex 1 (PRC1) is one of the two classes of Polycomb Repressive complexes, the other being PRC2. Polycomb-group proteins play a major role in transcriptional regulation during development.

2024年12月25日 · PRC1 (Protein Regulator Of Cytokinesis 1) is a Protein Coding gene. Diseases associated with PRC1 include Bladder Cancer. Among its related pathways are Signaling by Rho GTPases and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include identical protein binding and microtubule binding.

2021年3月15日 · PcG proteins function on chromatin and can form two distinct complexes with different enzymatic activities: Polycomb repressive complex 1 (PRC1) is a histone ubiquitin ligase and PRC2 is a...

2024年3月22日 · We propose that PRC1 composition can modulate condensate properties, providing crucial regulatory flexibility across developmental stages.

We demonstrate that PRC1, a mitotic spindle-associated Cdk substrate that is essential to cell cleavage, is a microtubule binding and bundling protein both in vivo and in vitro. Overexpression of PRC1 extensively bundles interphase microtubules, but …

Yeast two-hybrid experiments as well as biochemical studies have revealed that the PcG proteins assemble to form two main protein complexes called Polycomb repressive complexes 1 (PRC1) and 2 (PRC2) [2, 3]. PRC1 and PRC2 are both histone-modifying machines.

2021年8月16日 · Using single-cell gene expression analysis, we reveal that PRC1 acts uniformly within the cell population and that repression is achieved by controlling transcriptional burst frequency. These...

2021年6月21日 · Polycomb repressive complex 1 (PRC1) is an essential chromatin-modifying complex that monoubiquitinates histone H2A and is involved in maintaining the repressed chromatin state....

PRC1 is a nuclear protein in interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell midbody during cytokinesis.