2013年3月5日 · VHL-deficient PRC3 cells were more sensitive to treatment with 968, compared to the VHL-reconstituted WT8 cells (Figure 7A). To confirm that this is not only a cell-line-specific …

Microvasculature with abundant endothelial fenestration (EFs) on VHL null clear cell renal cell carcinoma (ccRCC) might be vascular endothelial growth factor (VEGF)‐dependent capillaries …

2011年10月24日 · Short-hairpin RNA (shRNA)-mediated knockdown of JunB in 786-O and A498 VHL null ccRCC cells suppressed their invasiveness. In addition, JunB knockdown …

2004年2月1日 · VHL−/− cells constitutively overexpress hypoxia-inducible genes through both transcriptional and posttranscriptional mechanisms and form tumors when injected into nude …

2005年6月14日 · In the paired cell lines, PRC3 and WT8, EGFR protein was elevated post-transcriptionally in the VHL mutant and EGF-stimulated phosphorylation was prolonged. We …

The VHL tumor suppressor protein (pVHL) is part of an E3 ubiquitin ligase that targets HIF for destruction. pVHL-defective renal carcinoma cells exhibit increased NF-kB activity but the …

786-O cells express HIF-2 ␣ but not HIF-1 ␣ . 786-O (PRC-3) is a VHL -defective renal carcinoma cell line, whereas 786-O (WT-8) cells have been stably transfected with functional …

2013年3月5日 · Herein, we performed MFA using a combined model of [U-13 C 6]glucose and [1-13 C 1]glutamine tracer data sets from the 786-O derived isogenic clones PRC3 (VHL …

2003年12月5日 · Cell Culture and Reagents—The pVHL-deficient 786-O cell clones stably expressing wild type VHL (WT10), truncated VHL (1–115) or empty plasmid (PRC3) were …

2007年12月13日 · Loss of the tumor suppressor gene von Hippel–Lindau (VHL) plays a key role in the oncogenesis of clear cell renal cell carcinoma (CCRCC). The loss leads to stabilization …