HGPRT is a transferase that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. This reaction transfers the 5-phosphoribosyl group …

HPRT catalyzes the salvage synthesis of inosine monophosphate (IMP) and guanosine monophosphate (GMP) from the purine bases hypoxanthine and guanine respectively, utilizing …

2019年9月25日 · Using biochemical, structural and evolutionary analyses of HPRT homologs across diverse bacterial phyla, we identify a conserved (p)ppGpp binding motif and identified a …

次黄嘌呤鸟嘌呤磷酸核糖转移酶 (Hypoxanthine-guanine phosphoribosyltransferase, HPRT)是一种细胞质酶, 在体内广泛存在, 它不仅参与嘌呤碱基的补救合成途径, 而且关系到嘌呤类药物的代 …

Hypoxanthine-guanine phosphoribosyltransferase (HPRT) catalyzes the salvage synthesis of IMP and guanosine monophosphate (GMP) from the purine bases hypoxanthine and guanine, …

Deficiencies of HPRT are usually associated with increased concentrations of PRPP and increased levels of APRT activity in erythrocytes. We report the case of a male with a partial …

Hypoxanthine–guanine phosphoribosyltransferase (HPRT) (EC 2.4.2.8) catalyzes salvage of the purine bases hypoxanthine and guanine to their respective monophosphate nucleosides (IMP …

2019年9月25日 · The alarmone (p)ppGpp regulates diverse targets, yet its target specificity and evolution remain poorly understood. Here, we elucidate the mechanism by which basal …

HGPRTase functions primarily to salvage purines from degraded DNA to reintroduce into purine synthetic pathways. In this role, it catalyzes the reaction between guanine and phosphoribosyl …

2010年10月5日 · Human hypoxanthine guanine phosphoribosyltransferase (HPRT) (EC 2.4.2.8) is an important enzyme in the salvage pathway of purine nucleotides. It catalyzes the transfer of …