Androgen Mediated Regulation of Endoplasmic Reticulum-Associated ...
2017年1月16日 · ERAD genes found to be upregulated in prostate cancer tissues and silencing expression of Hrd1, SVIP, and gp78 reduced the in vitro migration and malignant …
Direct visualization of degradation microcompartments at the ER ... - PNAS
Endoplasmic reticulum-associated degradation (ERAD) is an essential process that removes misfolded proteins from the ER, preventing cellular dysfunction and disease. While most of the …
Augmented ERAD (ER-associated degradation) activity in ... - AAAS
2022年1月21日 · Thus, the ER-associated degradation (ERAD) complex—which removes misfolded and unfolded proteins to maintain proteostasis in the ER— plays an indispensable …
Progesterone regulates the endoplasmic reticulum-associated
2022年11月29日 · More strikingly, we found progesterone regulates AR signaling by modulating the nuclear transactivation of AR. Herein, we defined that progesterone hormone positively …
什么是内质网相关降解（ERAD）？国自然开始了，研究一下！
细胞糖蛋白的分泌并维持稳定的糖蛋白稳态主要通过 ERQC （内质网糖蛋白折叠质量控制）和ERAD来实现。 ERAD作用的底物的范围是相当广泛的，从ER定位的错误组装蛋白到错折叠 …
Expression of ERAD components in different prostate cell lines.
The expression levels of ERAD components, AR and PSA levels in prostate cell lines were determined by immunoblotting. Actin was used as the loading control in all immunblotting …
Triiodothyronine positively regulates endoplasmic reticulum …
2023年9月1日 · Our results showed that AR, endogenous PSA and secreted PSA levels induced by T3 were effectively reversed by bicalutamide treatment. As expected, R1881 strongly …
Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD ...
Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for the …
准化表观扩散系数值, 即ADCn(ADC 病灶/ADC 外周带)。比较ADCn、PSAD 在两组间差异是否具有统计学意义, 采用受试者工作特性曲线(ROC)比较�. 者对 PI-RADS v2.1 评分3 分病灶 …
ERAD genes found to be upregulated in prostate cancer tissues and silencing expression of Hrd1, SVIP, and gp78 reduced the in vitro migration and malignant transformation of LNCaP cells.