2022年12月1日 · Liposomes (PSLs)-incorporated multilayers were successfully constructed on titanium surfaces using the sequential liposome stabilization strategy through the multilamellar formation and covalent crosslinking of adjacent phospholipids. The PSL-multilayer coating enhanced bone regeneration and osseointegration of titanium implants in rat bones.

2024年10月1日 · Here we demonstrate that collagen patches releasing phosphatidylserine liposomes (PSLs) promote M1-to-M2 macrophage polarization and are effective for simultaneous healing of bone and muscle.

2011年4月4日 · Phosphatidylserine (PS)-containing liposomes (PSLs) strongly inhibit inflammatory bone loss in adjuvant arthritic (AA) rats. This effect was attributed to the inhibition of...

本研究证明了在植入物上构建的 PSL 多层诱导局部 M1 到 M2 巨噬细胞极化的优势，以实现有效的骨再生和骨整合（骨与植入物整合）。 从机制上讲，M2 巨噬细胞促进成骨但抑制破骨细胞生成，M1 巨噬细胞反之亦然. 我们相信，我们的研究对设计用于再生医学的新型免疫调节生物材料做出了重大贡献，因为它是第一个验证 PSL 对组织再生益处的研究。 An appropriate immune microenvironment, governed by macrophages, is essential for rapid tissue regeneration after …

Phosphatidylserine (PS)-containing liposomes (PSLs) strongly inhibit inflammatory bone loss in adjuvant arthritic (AA) rats. This effect was attributed to the inhibition of osteoclastogenesis through the secretion of prostaglandin E(2) and transforming growth factor-β1 by osteoclast precursors after …

2010年3月15日 · To further prove the essential roles of TGF-β1 and PGE 2 in PSL-induced inhibitory effects on the trabecular bone loss in AA rats, we finally quantified the trabecular bone network of the bones in the ankle joints at 14 d posttreatment with PSLs or TGF-β1 and PGE 2 together on AA rats (28 d after CFA injection) using μCT analysis. The μCT ...

在本研究中，为了模拟 mgf-e8，制备了呈递 rgd 肽的 psl（rgd-psl），并研究了它们对巨噬细胞的免疫调节作用和大鼠颅骨缺损的骨组织再生。rgd 肽增强了巨噬细胞对 psl的吞噬作用，尤其是当 psl 含有 3% rgd 时。

2021年12月1日 · In this study, to mimic MGF-E8, PSLs presenting RGD peptide (RGD-PSLs) were prepared, and their immunomodulatory effects on macrophages and the bone tissue regeneration of rat calvarial defects were investigated. RGD peptides enhanced the phagocytosis of PSLs by macrophages, especially when the PSLs contained 3% RGD.

目的：探究牛奶外泌体（mEXO）减少泼尼松龙（PSL）治疗杜兴肌肉萎缩症（DMD）的药物不良反应的效果。 方法：将超速离心法收集的mEXO与PSL共孵育得到生物纳米药物（mEXOPSL）；通过高效液相色谱（HPLC）检测药物装载效率；对DMD模型 mdx小鼠给予口服治疗；监测mdx小鼠体重和体长变化，评估mEXO减轻PSL引起的生长抑制不良反应的效果，利用苏木素-伊红（HE）染色和micro-CT分析骨体积分数（BV/TV）、骨小梁数目（Tb.N）、骨小 …

2022年2月28日 · PSL-Cur can significantly increase the thickness and volume of cortical and trabecular bone mass as well as the mechanical bone strength in animals. Experimental findings proposed PSL-Cur consumption as a proper and safe supplementary medication in the controlling of bone loss in patients with a high risk of osteoporosis.