磷酸酯酶与张力蛋白同源物 （英語： Phosphatase and tensin homolog，简称为 PTEN）是一种在人体中由 PTEN 基因 编码的 蛋白质 [2]。 该基因的突变是多种 癌症 进展过程的环节之一。 PTEN 通过其 磷酸酯酶 蛋白产物而行使一种 抑癌基因 的作用。 这一磷酸酯酶参与了 细胞周期 的调节，阻止细胞过快地生长与分裂 [3]。 其为 癌微RNA MIRN21 的靶之一。 该基因被鉴定为一种肿瘤抑制物，在多种癌症中往往处于变异状态。 该基因编码的蛋白质是一种磷脂酰肌醇-3,4,5-三磷 …

Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. [6] Mutations of this gene are a step in the development of many cancers , specifically glioblastoma, lung cancer, breast cancer, and prostate cancer.

磷酸酶基因（pten）是迄今发现的第一个具有双特异磷酸酶活性的 抑癌基因,也是继p53基因后另一个较为广泛地与肿瘤发生关系密切的基因.pten蛋白在 细胞生长 、凋亡、粘附、迁移、浸润等方面具有重要作用.

1 pten基因研究概况. pten是迄今发现的第一个具有双重特性磷酸酶活性的肿瘤抑制基因，有 脂质磷酸酶 和 蛋白磷酸酶 双重特异性，在细胞内多条信号传导途径调控中起着重要作用，自发现以来受到众多学者的关注。pten脂质磷酸酶的活性可使磷脂酰肌醇三磷酸 ...

2024年12月25日 · PTEN (Phosphatase And Tensin Homolog) is a Protein Coding gene. Diseases associated with PTEN include Cowden Syndrome 1 and Macrocephaly/Autism Syndrome. Among its related pathways are Prolactin Signaling and PIP3 activates AKT signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and magnesium ion binding.

The PTEN gene provides instructions for making an enzyme that is found in almost all tissues in the body. The enzyme acts as a tumor suppressor, which means that it helps regulate cell division by keeping cells from growing and dividing (proliferating) too rapidly or in an uncontrolled way.

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a phosphatase that is frequently altered in cancer. PTEN has phosphatase-dependent and - independent roles; and genetic alterations in PTEN lead to deregulation of protein synthesis, cell cycle, migration, growth, DNA repair, and survival signaling.

2018年6月1日 · The tumour suppressor PTEN regulates various cellular processes, including maintenance of genomic stability, cell survival, migration, proliferation and metabolism.

PTEN基因（gene of phosphate and tension homology deleted on chromosome ten，PTEN），又称为MMAC1（mutated in multiple advanced cancer 1）和TEP1（TGF-regulated and epithelial cell -enriched phosphatase）。定位于染色体10q23.3，由9个外显子组成，编码由403个氨基酸组成的蛋白质，具有磷酸酯酶的活性。

Although the role of PTEN in cancers has long been appreciated, it is also emerging as an important factor in other diseases, such as diabetes and autism spectrum disorders. Our understanding of PTEN function and regulation will hopefully translate into improved prognosis and treatment for patients suffering from these ailments.