2020年12月9日 · To identify proteins that interact with nuclear neddylated PTEN, the nuclear fractions of shPTEN + PTEN-Nedd8 stable MCF-7 cells were subject to IP followed by mass spectrometry analysis.

2012年6月19日 · Our data demonstrate a molecular mechanism whereby SUMO1 modification is required for PTEN tumour suppressor function by controlling PTEN membrane association and regulation of the...

2019年5月17日 · Pharmacological inactivation of WWP1 by I3C in either Myc -driven or Pten heterozygous mice reactivates PTEN, leading to potent suppression of tumorigenesis driven by the PI3K-AKT pathway.

2021年7月12日 · PTEN exerts its tumor suppression function through the dephosphorylation of PIP3 and antagonizing PI3K-Akt signaling pathway with its lipid phosphatase activity. 3, 4 The previous study also...

PTEN脂质磷酸酶的活性可使磷脂酰肌醇三磷酸（PIP3）去磷酸化转变为磷脂酰肌醇二磷酸而失活，继而抑制Pl3K/AKT通路，抑制细胞的生长、调控细胞周期。

PTEN is a phosphatidylinositol-3,4,5-triphosphate (PIP3) phospholipid phosphatase that is commonly mutated or silenced in cancer. PTEN’s catalytic activity, cellular membrane localization, and stability are orchestrated by a cluster of C-terminal ...

2024年12月2日 · Zhang et al. show that PTEN is secreted as a soluble protein by the TMED10-mediated unconventional protein secretion pathway into the extracellular space, where it exerts a cytokine-like role by binding with PLXDC2 on macrophages to sequentially activate JAK2-STAT1 signaling, reprogram macrophages, and drive antitumor immunity.

2024年10月24日 · Numerous studies suggest that PTEN expression levels in tumors could be a valuable biomarker for cancer diagnosis, treatment, and predicting patient outcomes. This paper provides a comprehensive review of the biological function, regulatory mechanisms, and post-translational modifications of PTEN.

2024年10月24日 · PTEN regulates essential cellular processes involved in tumorigenesis. Mutations or deletions in the PTEN gene often correlate with unfavorable prognosis and increased cancer recurrence. Numerous studies suggest that PTEN expression levels in tumors could be a valuable biomarker for cancer diagnosis, treatment, and predicting patient outcomes.

PTEN是肿瘤研究里炙手可热的明星分子，由于其可以通过脂质磷酸酶功能抑制磷脂酰肌醇-3-激酶（PI3K）的活性，成为重要的肿瘤抑制基因之一。