2017年5月19日 · We demonstrate that TGF- β triggers apoptosis of wild-type polarized endometrial epithelial cells by a Smad3-dependent activation of PTEN transcription, which results in the inhibition of...

Here, we have unveiled a PTEN-Smad3 regulatory loop that provides a new insight in the complex cross talk between TGF-β/Smad and PI3K/AKT signaling pathways. We demonstrate that TGF-β triggers apoptosis of wild-type polarized endometrial epithelial cells by a Smad3-dependent activation of PTEN transcription, which results in the inhibition of ...

Our findings suggest that the TGFβ-PI3K-PTEN proliferative pathway is unmasked with loss of the suppressive TGFβ-SMAD pathway in colon cancer cells, converting TGFβ’s dominant role as a tumor suppressor into a tumor promoter.

2022年2月8日 · The identification of circPTEN1 provides a new direction for PTEN investigation, and elucidation of circPTEN1/TGF-β/Smad signaling may pave the way for the development of a potential therapeutic strategy for the suppression of cancer progression.

2022年2月8日 · Our study uncovered a novel PTEN gene-generated circRNA with a tumor suppression function, and further revealed the mechanism of circPTEN1 in CRC metastasis mediated by TGF-β. The identification of circPTEN1 provides a new direction for PTEN investigation, and elucidation of circPTEN1/TGF-β/Smad sig …

2022年2月8日，北京大学基础医学院尹玉新教授团队在Molecular Cancer在线发表了题为“circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad...

2025年3月11日 · Herein, we reported a novel mechanism in control of PINK1 transcription by SMAD Family Member 3 (SMAD3), an essential component of the transforming growth factor beta (TGFβ)-SMAD signaling pathway. First, we observed that mitochondrial depolarization promotes PINK1 transcription, and SMAD3 is likely to be the nuclear transcription factor ...

Here, we have unveiled a PTEN-Smad3 regulatory loop that provides a new insight in the complex cross talk between TGF- /Smad and PI3K/AKT signaling pathways. We. PTEN transcription, which...

2022年2月8日，北京大学基础医学院尹玉新教授团队在Molecular Cancer在线发表了题为circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling 的研究论文，鉴定了一种由抑癌基因PTEN编码的环状RNA，命名为circPTEN1。circPTEN1可以干扰TGF ...

2021年10月5日 · PTEN is a protein highly altered in endometrial cancer. PTEN mutation or deficiency leads to the activation of other downstream proteins that are important to the development of cancers. In this study, we have identified the SMAD2/3 proteins as targets of PTEN deficiency.