2024年9月1日 · We found that chemogenetic activation of NPY DRN/vlPAG neurons significantly reduced the number of 2-h novelty stress-induced Fos + neurons in the PVN (Fig. 3a, b), a key …

2013年2月5日 · Mechanistically, a key change induced by Arc NPY signaling is a marked Y1 receptor-mediated reduction in tyrosine hydroxylase (TH) expression in the hypothalamic …

2018年12月1日 · One of the main brain regions where NPY exerts its effects on food intake and energy expenditure is the hypothalamic paraventricular nucleus (PVN). NPY-containing axons …

2010年11月19日 · Circulating leptin, by affecting the activity of neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons in the ARC, regulates synthesis of NPY/agouti-related …

2011年10月1日 · Neuropeptide Y (NPY) is a highly conserved neuropeptide with orexigenic actions in discrete hypothalamic nuclei that plays a role in regulating energy homeostasis. …

The hypothalamic paraventricular nucleus (PVN) is a major locus where NPY exerts its effects on energy homeostasis. We investigated how NPY exerts its effect within the PVN. Methods: …

1997年7月1日 · Neuropeptide Y (NPY) is a powerful inducer of food intake with a key site of action in the paraventricular nucleus (PVN) of the hypothalamus. An effective method for …

在本研究中，我们通过与麻醉雄性大鼠下丘脑室旁核 (PVN) 和下丘脑背内侧 (DMH) 中的 Y1 受体 (NPY1R) 结合，研究了外源性和内源性 NPY 对 BAT SNA 的抑制作用。 使用雄性N py1r - cre …

2014年4月1日 · In chloralose-anaesthetized female rats, nanoinjection of NPY into the paraventricular nucleus of the hypothalamus (PVN) dose-dependently suppressed lumbar …

Neuropeptide Y (NPY) is one the most potent orexigenic peptides found in the brain. It stimulates food intake with a preferential effect on carbohydrate intake. It decreases latency to eat, …