2024年12月25日 · PXK (PX Domain Containing Serine/Threonine Kinase Like) is a Protein Coding gene. Diseases associated with PXK include Systemic Lupus Erythematosus and Lupus Erythematosus. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and nucleotide binding.

PX domain containing serine/threonine kinase also known as PXK is a protein which in humans is encoded by the PXK gene. [1][2] PXK binds to the Na⁺/K⁺-ATPase beta-1 (ATP1B1) and beta-3 (ATP1B3) subunits and modulates both Na⁺/K⁺-ATPase enzymatic and ion pump activities. [2] ^ "Entrez Gene: PX domain containing serine/threonine kinase".

Broad expression in thyroid (RPKM 17.1), brain (RPKM 11.4) and 24 other tissues. 该基因编码含有 phox (PX) 结构域的蛋白质，该蛋白质可能参与突触传递和配体诱导的表皮生长因子的内化和降解。 该基因的变异可能与系统性红斑狼疮 (SLE) 的易感性有关。 可变剪接导致多个转录本变体。 [RefSeq 提供，2014 年 1 月]

2025年2月8日 · Gene ID: 54899, updated on 8-Feb-2025. This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE).

PXK contains an N-terminal PX-like domain predicted to bind phosphoinositides, a putative protein kinase domain in the central region, which has greatest similarity to Drosophila slob, and a number of polyproline motifs. The authors identified a …

In summary, we present four new regions having genetic associations with SLE in women of European descent: ITGAM, KIAA1542, PXK and rs10798269. In addition, we identify other genomic regions possibly associated with SLE and confirm associations with the HLA region and with IRF5, STAT4, FCRG2A and PTPN22. These genetic factors should prove to be ...

PX domain-containing protein kinase-like protein, modulator of Na,K-ATPase. MONaKA modulates brain Na,K-ATPase by binding tightly to its beta1 and beta3 subunits, and may thereby participate in the regulation of electrical excitability and synaptic transmission.

2015年1月8日 · Genome wide association studies have identified variants in PXK that confer risk for humoral autoimmune diseases, including systemic lupus erythematosus (SLE or lupus), rheumatoid arthritis and more recently systemic sclerosis. While PXK is involved in trafficking of epidermal growth factor Receptor …

目的:探讨系统性红斑狼疮(sle)患者外周血白细胞中含丝氨酸/苏氨酸激酶的pxk结构域(pxk)mrna表达水平的变化,分析pxk mrna的表达与sle临床指标的相关性。 方法:收集60例SLE患者和30名正常对照组的临床资料和血液标本,采用反转录聚合酶链反应技术半定量检测PXKMRNA在外 ...

This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to …