Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene. [5] [6] PAK2 is one of three members of Group I PAK family of serine/threonine kinases. …

2024年12月25日 · PAK2 (P21 (RAC1) Activated Kinase 2) is a Protein Coding gene. Diseases associated with PAK2 include Knobloch Syndrome 2 and Knobloch Syndrome. Among its …

2025年2月1日 · In neuronal cells, PAK2 has been identified as a key regulator of glucose uptake, pyruvate metabolism, and PKM2-associated feedback mechanisms, which highlight PAK2's …

2021年10月25日 · PAK2 facilitates STAT5 translocation in CML as well, and drives the Rac-PAK-Cofilin pathway, leading to increased ROS production. Additionally, PAK6 drives the ERK and …

In this review, we discuss the mechanisms of Pak activation in cancer, the key substrates for this family of kinases that mediate their developmental and oncogenic effects, and how small …

This review highlights the biological significance of PAK2 in cancer and its interactions with critical signaling pathways, offering valuable insights for future research. We also discuss the major …

2023年2月22日 · We demonstrated that PAK2’s interaction with PLK1 protected it from degradation by APC/C Cdh1, and that it promoted meiotic progression and bipolar spindle …

2024年12月15日 · In various types of cancers, PAK2 has been implicated in the regulation of cancer cell proliferation, cell cycle, and apoptosis. In addition, recent studies have shown that …

PAK2, a gene frequently amplified in adult T-Cell Leukemia/Lymphoma (ATLL), facilitates CADM1-mediated stromal interaction and promotes survival of ATLL cells. The pan-PAK …

PAK（p21激活的激酶）是肌动蛋白动力学、细胞增殖和细胞存活的关键调节剂。 同时PAK还被认为是肌动蛋白细胞骨架和运动的主要调节因子。 由于它们在肌动蛋白重塑中的核心作用及其 …