Pathology Outlines - Intestinal metaplasia
2022年11月18日 · Gastric intestinal metaplasia (IM) is defined as a metaplastic condition wherein the normal gastric mucosa is replaced by intestinal type of mucosa replete with mucin producing goblet cells, with or without Paneth cells and absorptive cells
Pathology Outlines - Inflammatory bowel disease, indeterminate …
2021年4月26日 · Paneth cell metaplasia (Paneth cells are normally absent distal to the mid transverse colon) Crypt architectural distortion (branched, dilated and disorganized crypts) Microscopic features that are still compatible with ulcerative colitis and do not warrant a diagnosis of Crohn's disease or IBD, indeterminate type ( Mod Pathol 2015;28:S30 , J ...
Pathology Outlines - Anatomy & histology
2022年6月8日 · Paneth cells: Paneth cells have a triangular shape with densely eosinophilic cytoplasmic granules Nuclei are basally located, unlike enteroendocrine cells described above, a distinction important in the left colon, since the presence of Paneth cells in this part of colon is abnormal and could be a sign of chronic injury
Pathology Outlines - Nonneoplastic metaplasia
2024年3月19日 · Paneth cell-like metaplasia. Paneth cell-like metaplasia is positive for P504S, similar to cancer. Answer A is incorrect because although mucinous metaplasia is PAS positive and diastase resistant, it is not positive for P504S (AMACR). Answer C is incorrect because squamous metaplasia is negative for both of these markers.
Pathology Outlines - Ulcerative colitis
2021年5月11日 · Paneth cell metaplasia or hyperplasia Features of activity Neutrophilic inflammation with cryptitis, crypt abscess or ulceration Patients who have had symptoms for a short duration, longstanding disease or who have undergone therapy may have histological changes that may make microscopic diagnosis difficult (Histopathology 2014;64:317)
Pathology Outlines - Lymphocytic colitis
2020年7月28日 · Paneth cell metaplasia Acute infectious colitis: Edema Luminal, lamina propria, surface neutrophils and cryptitis No mononuclear inflammation or increased intraepithelial lymphocytes Checkpoint inhibitor induced colitis (Cancer 2019;125:1768): Scattered crypt apoptosis Basal lymphoplasmacytosis
Pathology Outlines - Tubulovillous / villous adenoma
2022年6月21日 · Paneth cell metaplasia is a frequent finding (17 - 23%), especially in proximal locations; osseous metaplasia has been reported (Histopathology 2021;78:348) Neuroendocrine metaplasia refers to the presence of scattered foci of neuroendocrine cells that lack significant nuclear atypia, mitotic activity or necrosis; these cells comprise 30% of ...
Pathology Outlines - Collagenous colitis
2020年8月3日 · Paneth cell metaplasia can be seen Up to 8% of cases can have crypt atrophy or irregularity (Am J Surg Pathol 2002;26:1414) Subepithelial multinucleated giant cells can be seen but have no clinical significance (Pathology 2008;40:671)
Intestinal metaplasia - Pathology Outlines
2022年7月18日 · Intestinal metaplasia with goblet cells is noted in 33% of urachal remnants (J Urol 1982;127:40) Adenocarcinoma - primary, metastatic or from renal pelvis / ureter : Infiltrative with extensive muscle invasion, anaplasia, mitotic figures and extensive mucinous pools ( Hum Pathol 1997;28:1152 )
Pathology Outlines - Acute self limited colitis
2022年12月12日 · Paneth cells are normally absent in the left colon. When present, they serve as an indicator for chronic mucosal injury. However, Paneth cells are normally present in the right colon; hence, sigmoid colon is the correct choice. If Paneth cell metaplasia is seen in the sigmoid colon, this is an indicator for chronic mucosal injury. Comment Here