2024年12月25日 · PARK7 (Parkinsonism Associated Deglycase) is a Protein Coding gene. Diseases associated with PARK7 include Parkinson Disease 7, Autosomal Recessive Early …

DJ1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. [5] . Its weak glyoxalase activity has been verified by many labs, [6] however the …

The PARK7 gene provides instructions for making the DJ-1 protein. This protein is found in many tissues and organs, including the brain. Studies indicate that the DJ-1 protein has several …

该基因的产物属于肽酶 C56 蛋白家族。 它作为雄激素受体依赖性转录的正调节剂。 它也可以作为氧化还原敏感的伴侣，作为氧化应激的传感器，并且它显然可以保护神经元免受氧化应激和细 …

2022年1月25日 · Here we report that PARK7, an enzyme mutated in hereditary Parkinson's disease, prevents damage of proteins and metabolites caused by a metabolite of glycolysis. …

Here we report that PARK7, an enzyme mutated in hereditary Parkinson’s disease, prevents damage of proteins and metabolites caused by a metabolite of glycolysis. We found that the …

Oxidized PARK7 acts as a co-chaperone-like protein that binds the ER-derived chaperone R-HSPA5, a member of the HSPA/HSP70 family. By forming a complex with PARK7 (and …

Mutations in the PD-associated gene PARK7 alter the structure and function of the encoded protein DJ-1, and the resulting autosomal recessively inherited disease increases the risk of …

2025年2月9日 · It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it …

帕金森病7型，常染色体隐性早发型的一个重要基因是PARK7（帕金森病相关去糖基酶），其相关通路/超级通路包括蛋白水解潜在SUMO-1通路。 相关组织包括大脑和皮层，相关表型包括焦 …