Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly [ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. [5] . It is the most abundant of the PARP family of enzymes, …

2017年7月5日 · PARP1 is an abundant nuclear protein that post-translationally attaches a negatively charged polymer termed poly (ADP-ribose) (PAR) to itself and to multiple target proteins.

Poly (ADP-ribose) polymerase 1 (PARP1), the best-studied isoform of the nuclear enzyme PARP family, plays a pivotal role in cellular biological processes, such as DNA repair, gene transcription, and so on. PARP1 has been found to be overexpressed in various carcinomas.

2024年12月25日 · PARP1 (Poly (ADP-Ribose) Polymerase 1) is a Protein Coding gene. Diseases associated with PARP1 include Diphtheria and Fallopian Tube Carcinoma. Among its related pathways are Apoptosis and survival FAS signaling cascades and Transcription-Coupled Nucleotide Excision Repair (TC-NER).

Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that catalyzes poly-ADP ribosylation in eukaryotic cells. In addition to maintaining genomic integrity, this nuclear enzyme is also involved in transcriptional regulation.

Poly(ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair pathways, including the base excision repair (BER), non-homologous end joining (NHEJ), homologous recombination (HR), and Okazaki-fragment processing …

PARP1 was first described by its role in the repair of alkylating agent-induced DNA base damages and also single strand breaks (SSBs). PARP1 is involved in base excision repair (BER) via recruitment of BER scaffold protein XRCC1 (X-ray cross-complementing group 1) …

2020年9月3日 · Poly (ADP-ribose) polymerase 1 (PARP1) cleaves NAD + to ADP-ribose and nicotinamide, and covalently attaches ADP-ribose to an acceptor protein. Additional NAD + molecules can be cleaved and...

Poly (ADP-ribose) polymerase 1 (PARP1) plays critical roles in DNA repair, chromatin regulation, and cellular equilibrium, positioning it as a pivotal target for therapeutic interventions in cancer and central nervous system (CNS) disorders.

2024年9月20日 · Poly (ADP-ribose) polymerase 1 (PARP1) is a crucial member of the PARP family, which modifies targets through ADP-ribosylation and plays key roles in a variety of biological processes. PARP inhibitors (PARPis) hinder ADP-ribosylation and lead to the retention of PARP1 at the DNA lesion (also known as trapping), which underlies their toxicity.