2024年12月14日 · PATINA: A randomized, open label, phase III trial to evaluate the efficacy and safety of palbociclib + Anti-HER2 therapy + endocrine therapy (ET) vs. anti-HER2 therapy + ET after induction treatment for hormone receptor positive …

ession. Participants were randomized to palbociclib plus anti-HER2 therapy (H or HP) plus ET or anti-HER2 therapy plus E. alone. ET options included aromatase inhibitor (AI) or fulvestrant, with ovarian suppression required for premenopausal p.

2024年12月14日 · Phase 2 trials suggest synergistic antitumor activity and potential efficacy of palbociclib when combined with anti-HER2 therapy, especially in HR+/HER2+ breast cancer.

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2017年8月22日 · The Alliance Foundation Trials, LLC (AFT), in conjunction with Pfizer and six international cancer research groups, today announced the launch of PATINA – a randomized, open-label, Phase 3 clinical study of the cyclin-dependent kinase 4/6 (CDK 4/6) inhibitor palbociclib (also known as IBRANCE®).

Results from phase 2 clinical trials point to synergistic antitumor activity and potential efficacy of palbociclib when given in combination with anti-HER2 therapy (tx), particularly in HR+/HER2+ breast cancer.

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2024年12月13日 · Otto Metzger, MD, medical oncologist at the Dana-Farber Cancer Institute, shared potentially practice-changing data from the phase III academic AFT-38 PATINA study, which demonstrated a clinically meaningful improvement in progression-free survival (PFS) with addition of palbociclib to anti-HER2 and endocrine therapy in patients with HR+ HER2+ m...

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2024年12月12日 · The AFT-38 PATINA Phase III trial demonstrated a clinically meaningful 15.2-month PFS improvement with palbociclib added to anti-HER2 plus ET, with a manageable toxicity profile, and may represent a new standard of care for patients diagnosed with HR+ HER2+ advanced breast cancer.