Paxillin is a protein that in humans is encoded by the PXN gene. Paxillin is expressed at focal adhesions of non-striated cells and at costameres of striated muscle cells, and it functions to adhere cells to the extracellular matrix .

Paxillin 是一种涉及胞外基质细胞黏附（黏着斑）位点上肌动蛋白-膜附着的细胞骨架蛋白。 Paxillin 在整合蛋白的信号传导中起着非常重要的作用，整合蛋白介导的细胞骨架的再组织需要 paxillin 酪氨酸残基的磷酸化。

Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of...

2024年9月7日 · 其中一种重要的蛋白质是paxillin。由于paxillin存在于所有细胞中，作为整合素与细胞骨架之间的桥梁，它也成为可视化黏着斑的标志。

2017年2月18日 · Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves an important scaffolding role at focal adhesions by recruiting structural and signaling molecules involved in cell movement and migration, when phosphorylated on …

2024年12月25日 · PXN (Paxillin) is a Protein Coding gene. Diseases associated with PXN include Papilloma and Prostate Cancer. Among its related pathways are Cell junction organization and Signaling by PTK6. Gene Ontology (GO) annotations related to this gene include protein kinase binding and integrin binding. An important paralog of this gene is TGFB1I1.

Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves an important scaffolding role at focal adhesions by recruiting structural and signaling molecules involved in cell movement and migration, when phosphorylated on specific Tyr and Ser residues.

Paxillin is a multi-domain scaffold protein that localizes to the intracellular surface of sites of cell adhesion to the extracellular matrix. Through the interactions of its multiple protein-protein binding modules, many of which are regulated by ...

Paxillin is a 68 kDa cytoplasmic protein that localizes to discrete sites of cell attachment to the extracellular matrix called focal adhesions. It is a multi-domain adapter protein capable of interacting with several structural and signaling proteins including vinculin, FAK, …

2001年10月1日 · Paxillin is a focal adhesion-associated, phosphotyrosine-containing protein that may play a role in several signaling pathways. Paxillin contains a number of motifs that mediate protein-protein interactions, including LD motifs, LIM domains, an SH3 domain-binding site and SH2 domain-binding sites.

2001年10月17日 · Paxillin is a focal adhesion-associated, phosphotyrosine-containing protein that may play a role in several signaling pathways. Paxillin contains a number of motifs that mediate protein–protein...

2017年1月1日 · Paxillin is an approximately 68-kDa multi-domain adapter protein featuring 5 LD motifs and 4 LIM domains. It is mainly a cytoplasmic protein enriched at focal adhesions in adherent cells but it can also translocate to the nucleus. Paxillin located at focal adhesions is one of linkers connecting extracellular matrix to the actin cytoskeleton.

The paxillin family of proteins, including paxillin, Hic-5, and leupaxin, are focal adhesion adaptor/scaffolding proteins which localize to cell-matrix adhesions and are important in cell adhesion and migration of both normal and cancer cells. Historically, the role of …

2019年8月7日 · Phosphorylation of the focal adhesion adaptor protein, paxillin, on serine 273 (S273) has been implicated as a key regulator of cell migration. Here, it is shown that phosphorylation on...

Paxillin and kindlin are essential regulatory proteins involved in cell adhesion, migration, and signal transduction. Paxillin influences cytoskeletal dynamics by interacting with multiple signaling proteins, while kindlin regulates integrin ...

2017年2月18日 · Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves an important scaffolding role at focal adhesions by recruiting structural and signaling molecules involved in cell movement and migration, when phosphorylated on …

2008年8月1日 · In this brief review of paxillin’s formative years, from its humble origins as a structural “peg”, we have focused primarily on highlighting advances in our understanding of the role of paxillin in coordinating the regulation of the cell’s motile machinery, as it is through this function that paxillin exerts the most significant impact ...

Paxillin and its family members are complex proteins that play major roles in modulating signaling throughout cells. When paxillin is outside the nucleus, it functions to modulate cell-cell interactions, regulate cytoskeletal changes, and modulate kinase signaling.

Paxillin is an important cell scaffold and cellular signaling protein, especially a key molecule of the Integrin-mediated downstream signaling transduction. This review summarizes the structure and functions of paxillin, and the research progress of its roles in neovascularization.

The paxillin family of intracellular scaffold proteins includes paxillin, Hic-5, and leupaxin, and all have been identified as key regulators of the cellular migration machinery in both 2- and 3-dimensional microenvironments.