Phosphodiesterase 1, PDE1, EC 3.1.4.1, systematic name oligonucleotide 5 ′-nucleotidohydrolase) is a phosphodiesterase enzyme also known as calcium - and calmodulin …

pde1有3种同功酶：pde1a、1b和1c，分别由不同的基因编码。 PDE1的 催化活性 是通过两个CaM结合区域来调控的，然而每种同功酶都有其被激活的独特Ca阈值。

PDE1：分布于平滑肌、心脏、肺、神经系统、生殖系统等;其作用包括调节平滑肌细胞收缩增殖、调节精子活动、调节免疫细胞功能等； PDE2：分布于肾上腺、神经系统、平滑肌、巨噬细胞 …

In the past decades, numerous PDE1 inhibitors with structural diversities have been developed and patented by pharmaceutical companies, providing drug candidates for exploring novel …

Cyclic nucleotide phosphodiesterases (PDEs) are superfamily of enzymes that regulate the spatial and temporal relationship of second messenger signaling in the cellular system. Among the 11 …

2021年10月1日 · PDE1 is a dual substrate (cAMP and cGMP) diesterase and a promising target for the treatment of heart disease, cancer, neurological disorder and other endocrine …

磷酸二酯酶1 ， pde1 ，ec 3.1.4.1，系统名称寡核苷酸5 ' -核苷酸氢化素酶）是一种磷酸二酯酶，也称为钙- 钙二糖蛋白依赖蛋白依赖性磷酸二酯酶。它是磷酸二酯酶的11个家族之一（pde1 …

PDE1 is a group of enzymes that require both calcium and calmodulin for their activity. They are encoded by three genes in humans and are involved in the degradation of cyclic nucleotides, …

环核苷酸磷酸二酯酶 (PDE) 通过将 cAMP 和/或 cGMP 水解成各自的核苷 5-主要单磷酸来调节细胞内环核苷酸浓度，从而在信号转导中发挥作用。 PDE1 家族的成员，例如 PDE1A，是 CA …

As a Class 1 phosphodiesterase, PDE1 hydrolyzes the 3' bond of 3'-5'-cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Here, we …