Compared to WT and PDE3B KO mice, cyclic AMP-PDE activity in membrane fractions prepared from the hearts of PDE3A KO mice was lower and not inhibited by cilostamide. The data suggest that PDE3A is the main subtype of PDE3 expressed in platelets and cardiac ventricular myocytes, and is responsible for the functional changes caused by PDE3 ...

2011年12月1日 · PDE3B, one of several enzymes which hydrolyze cAMP and cGMP, is expressed in cells of importance for the regulation of energy homeostasis, including adipocytes, hepatocytes, hypothalamic cells and β cells.

2002年7月8日 · These results indicate that a PI3K–PDE3B–cAMP pathway interacting with the Janus kinase 2 (Jak2)–Stat3 pathway constitutes a critical component of leptin signaling in the hypothalamus.

PDE3有两种基因亚型：PDE3A与PDE3B,分别位于染色体11与12上，由于起始密码子的不同，PDE3A又可分为PDE3A1、PDE3A2和 PDE3A3三种亚型,主要分布于心脏、血小板、血管平滑肌及卵母细胞中,具有调节心肌收缩力、血小板聚集、血管平滑肌收缩、卵母细胞成熟及肾素释放等作用。 PDE3B只有一种亚型PDE3B1，主要分布于脂肪细胞、肝细胞、精母细胞以及胰腺中，主要参与调节胰岛素，胰岛素样生长因子以及瘦素的信号传导，在肥胖和糖尿病等代谢性疾病中发挥 …

2019年8月6日 · Phosphodiesterases (PDEs), enzymes that degrade 3′,5′-cyclic nucleotides, are being pursued as therapeutic targets for several diseases, including those affecting the nervous system, the...

2024年11月27日 · We identified the PDE3B-cAMP-autophagy pathway as a key determinant of SLP-induced liver injury. Specifically, we found that PDE3B was elevated during SLP, which promoted a reduction of cAMP metabolites, triggering an AMPK-dependent autophagy process that led to liver injury in rats.

Phosphodiesterase 3B (PDE3B) is a critical regulator of cAMP signaling in adipocytes. Here we investigated the roles of PDE3B, PDE4, protein kinase B (PKB) and the exchange protein activated by cAMP 1 (Epac1), as well as lipolysis, in the regulation of …

Both PDE3A and PDE3B can hydrolyze cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), as well as being involved in the regulation of cardiovascular functions, insulin secretion, and the lipid metabolism (1-3).

Enables 3',5'-cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of angiogenesis; negative regulation of cell adhesion; and negative regulation of lipid catabolic process. Located in membrane. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]

2007年3月2日 · Cyclic nucleotide phosphodiesterases (PDEs), by hydrolyzing cAMP and cyclic GMP, regulate the amplitude, duration, and compartmentation of cyclic nucleotide-mediated signaling. In particular, PDE3 enzymes play a major role in regulating cAMP metabolism in the cardiovascular system.