PDE6 is a highly concentrated protein in retinal photoreceptors. With the presence of the GAF domain, PDE6 can actively bind to the cGMP. The inactive PDE6 in the dark allows cGMP to bind to cGMP gated ion channels.

The photoreceptor phosphodiesterase (PDE6) is a member of large family of Class I phosphodiesterases responsible for hydrolyzing the second messengers cAMP and cGMP. PDE6 consists of two catalytic subunits and two inhibitory subunits that form a ...

pde6是光感受器细胞进行光转换级联反应过程中重要的酶。它的活性受异三聚体g蛋白的调控。视杆细胞pde6全酶是一个四聚体蛋白质，它包括α、β两个大 催化亚基 和两个具有pde6抑制作用的小γ亚基。在暗反应光感受器，γ亚基有低水平的pde6活性。

2004年6月6日 · PDE6 is the primary regulator of cytoplasmic cGMP concentration in rod and cone photoreceptors (Figure 1). In the dark, PDE6 exists in an inactive form, and cGMP levels in the rod outer segment...

PDE6:分布于视觉系统中;其主要作用在于调节眼部视觉信号的传输; PDE7:分布于免疫系统、骨骼肌、内皮细胞、神经系统等;主要被报道作用于 T 细胞的活化及免疫调节方面; PDE8:分布于睾丸、脾、消化系统、肾、神经系统、心脏等;可调节心肌细胞对 β 受体激动的反应及 T 细胞活化等功能； PDE9:广泛分布于各种组织内，其作用尚鲜为人知，可能与脑组织中的 NO-cGMP 信号相关； PDE10:在脑、睾丸、甲状腺等组织中高表达;其功能与调节学习和记忆功能相关； PDE11:在 …

Photoreceptor phosphodiesterase 6 (PDE6 or PDE-6) is a protein complex family, which is highly concentrated in the retina. [1] [2] [3] [4]

Phosphodiesterase 6 (PDE6) is highly concentrated in the retina. It is most abundant in the internal membranes of retinal photoreceptors, where it reduces cytoplasmic levels of cyclic guanosine monophosphate (cGMP) in rod and cone outer segments in response to light.

2014年11月11日 · Photoreceptor phosphodiesterase (PDE6) is the central effector enzyme in visual excitation pathway in rod and cone photoreceptors. Its tight regulation is essential for the speed, sensitivity, recovery and adaptation of visual detection.

该基因编码杆特异性光感受器磷酸二酯酶 (PDE) 的 delta 亚基，PDE 是光转导级联中的关键酶。 牛体内的一种类似蛋白质在溶解膜结合的 PDE 中起作用。 除了它在 PDE 复合物中的作用外，编码的蛋白质被认为与蛋白质的异戊二烯基团结合，以将它们靶向称为纤毛的亚细胞器。 该基因的突变与 Joubert 综合征 22 有关。 可变剪接导致多个剪接变体。 [RefSeq 提供，2014 年 3 月] This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key …

2024年12月25日 · PDE6B (Phosphodiesterase 6B) is a Protein Coding gene. Diseases associated with PDE6B include Retinitis Pigmentosa 40 and Night Blindness, Congenital Stationary, Autosomal Dominant 2. Among its related pathways are Visual phototransduction and Regulation of activated PAK-2p34 by proteasome mediated degradation.