Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. [2] .

2024年12月25日 · PDGFRA (Platelet Derived Growth Factor Receptor Alpha) is a Protein Coding gene. Diseases associated with PDGFRA include Gist-Plus Syndrome and Gastrointestinal Stromal Tumor. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

Platelet-derived growth factor receptors (PDGFRs) belong to the receptor tyrosine kinase (RTK) family and serve the function of protein tyrosine kinases. PDGFRs are activated by binding to their ligand PDGFs, and involved in a variety of cellular processes, e.g. proliferation, migration, survival, and cancer development.

2023年5月1日 · The platelet derived growth factor receptor alpha (PDGFRα) has been regarded as a significant factor in the growth, angiogenesis, and spread of metastatic tumours. It served as a target for tyrosine kinase (TK) inhibitors that were developed for …

Platelet-derived growth factors (PDGFs) and their tyrosine kinase receptors (PDGFRs) have been implicated in the pathogenesis of a number of tumor types and play an important role in angiogenesis.

血小板衍生生長因子受體 （Platelet-derived growth factor receptors，PDGF-R）為 血小板衍生生長因子 （PDGF）蛋白質家族的 受體，位於 細胞膜 表面，屬於 酪胺酸激酶受體 （英语：receptor tyrosine kinase） 的一種。 PDGF的 次單元A 和 次單元B 在調控細胞 增殖 、 分化 、 生長 、 發育 上扮演相當重要的角色。 如果調控不正常，可能會引發 癌症 等多種疾病。 [2] PDGF-R有兩種型態，分別為 A 和 B，兩種型態來自於不同基因。

PDGFR alpha 是一类酪氨酸蛋白激酶，作为 PDGFA，PDGFB 和 PDGFC 的细胞表面受体，在调节胚胎发育、细胞增殖、存活和趋化性中起着至关重要的作用。 PDGFR alpha 在骨髓来源间充质干细胞的分化中起重要作用，是胚胎发育期间骨骼正常发育和头部闭合所必需的蛋白。 胃肠道内壁粘膜的正常发育，间充质细胞的募集和肠绒毛的正常发育也离不开 PDGFR alpha。 PDGFR alpha 在伤口愈合中的细胞迁移和趋化性、血小板活化、血小板颗粒分泌激动剂和凝血酶诱导的血小 …

肿瘤中pdgfr表达. pdgfr的表达与胃癌的浸润、淋巴结和远处转移及临床分期密切相关,与肿瘤大小、组织分型无关。可以认为：pdgfr表达越高，肿瘤越容易转移。 pdgfr在大肠癌中于vegf高表达，并且和k-ras基因突变有关，表达强度与肿瘤淋巴转移、分期呈正相关。

血小板衍生生长因子受体（Platelet-derived growth factor receptors，PDGF-R）为 血小板衍生生长因子 （PDGF）蛋白质家族的 受体，位于 细胞膜 表面，属于酪胺酸激酶受体的一种。 PDGF的次单元A和次单元B在调控细胞 增殖 、 分化 、 生长 、 发育 上扮演相当重要的角色。 如果调控不正常，可能会引发 癌症 等多种疾病。 血小板衍生生长因子受体（Platelet-derived growth factor receptors，PDGF-R）为血小板衍生生长因子（PDGF）蛋白质家族的受体，位于细胞膜表面， …

Platelet-Derived Growth Factors (PDGFs) are a family of four cystine-knot-type growth factors (PDGF-A, -B, -C and -D) which control the growth of connective tissue cells such as fibroblasts and smooth muscle cells [1, 2].