丙酮酸脱氢酶的结构、功能与相关疾病 - 知乎 - 知乎专栏
丙酮酸彻底氧化分解需要先转变为乙酰辅酶A，由丙酮酸脱氢酶复合体（pyruvate dehydrogenase complex，PDH或PDC）催化。这个反应需要三种酶连续催化，依次称为E1（丙酮酸脱氢 …
Dynamics of the mammalian pyruvate dehydrogenase complex
2025年1月22日 · Here, we report the in-situ architecture of intact mammalian PDHc by cryo-electron tomography. The organization of peripheral E1 and E3 components varies …
Structure of the Pyruvate Dehydrogenase Multienzyme Complex E1 ...
2002年3月28日 · The crystal structure of the recombinant thiamin diphosphate-dependent E1 component from the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDHc) …
丙酮酸脱氢酶 E1 亚基 alpha 1（PDHA1）基因 | MCE
This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate …
基础医学院张兴/常云杰团队Nature Communications揭示哺乳动物 …
2025年1月24日 · 本研究利用冷冻电子断层扫描技术（Cryo-Electron Tomography, Cryo-ET），首次揭示了哺乳动物完整PDHc的原位三维结构，详细分析了外周亚基E1和E3的数量与空间排 …
Stoichiometry and architecture of the human pyruvate ... - Science
PDHcs in prokaryotes and eukaryotes are composed of multiple copies of the enzymes pyruvate dehydrogenase (also termed E1 component), dihydrolipoamide acetyltransferase (E2 …
Structure of the native pyruvate dehydrogenase complex reveals …
2021年9月6日 · The pyruvate dehydrogenase complex (PDHc) is a large multienzyme complex that converts pyruvate into acetyl-coenzyme A and in E. coli the core of the PDHc is formed by …
Nat Commun | 张兴/常云杰团队揭示哺乳动物丙酮酸脱氢酶复合物 …
2025年1月29日 · 本研究利用冷冻电子断层扫描技术（Cryo-Electron Tomography, Cryo-ET），首次揭示了哺乳动物完整PDHc的原位三维结构，详细分析了外周亚基E1和E3的数量与空间排 …
丙酮酸脱氢酶 E1 亚基 β（PDHB）基因 | MCE
丙酮酸脱氢酶 (PDH) 复合物是一种核编码的线粒体多酶复合物，可催化丙酮酸向乙酰辅酶 A 和二氧化碳的整体转化，并提供糖酵解和三羧酸 (TCA) 循环之间的主要联系。 PDH 复合物由三种 …
Active-site changes in the pyruvate dehydrogenase multienzyme ... - PubMed
The first enzymatic component, E1 (EC 1.2.4.1), of the pyruvate dehydrogenase multienzyme complex (PDHc) utilizes thiamine diphosphate (ThDP) and Mg(2+) as cofactors. The structure …