2024年12月25日 · PDSS1 (Decaprenyl Diphosphate Synthase Subunit 1) is a Protein Coding gene. Diseases associated with PDSS1 include Coenzyme Q10 Deficiency, Primary, 2 and Coenzyme Q10 Deficiency Disease. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism of cofactors.

Decaprenyl-diphosphate synthase subunit 1 is an enzyme that in humans is encoded by the PDSS1 gene. [5] [6] The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl ...

2021年11月1日 · Using our previously constructed multiomic profiling of a TNBC cohort, we identified decaprenyl diphosphate synthase subunit 1 (PDSS1) as an essential gene for TNBC metastasis. PDSS1 expression was significantly upregulated in TNBC tissues compared with adjacent normal tissues and was positively associated with poor survival among patients with ...

Gene ID: 23590, updated on 9-Feb-2025. The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain.

2022年5月3日 · Decaprenyl diphosphate synthase subunit 1 (PDSS1) was considered a gene related to the synthesis of coenzyme Q. 5 Several studies showed that PDSS1 speed up the progression of some tumors, such as cutaneous melanoma, bladder cancer, breast cancer, and HCC. 6–11 Bioinformatics studies suggest that PDSS1 may be associated with hypoxia in the ...

2025年2月9日 · Clinical resource with information about PDSS1, Deafness-encephaloneuropathy-obesity-valvulopathy syndrome, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

该基因产物在聚异戊二烯侧链组装过程中催化异戊二磷酸生成所有反式聚异戊二烯焦磷酸，这是辅酶 Q 生物合成的第一步。 该蛋白质可能与线粒体内膜外周相关，但迄今为止尚未明确确定转运肽。 该基因的缺陷是辅酶 Q10 缺乏的原因。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is an Enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain.

2024年4月19日 · Using our previously constructed multiomic profiling of a TNBC cohort, we identified decaprenyl diphosphate synthase subunit 1 (PDSS1) as an essential gene for TNBC metastasis. PDSS1 expression was significantly upregulated in TNBC tissues compared to adjacent normal tissues and was positively associated with poor survival among TNBC patients.

2023年4月17日 · By searching EST databases for homologs of S. pombe Dps1, Saiki et al. (2005) identified human PDSS1, which they called DPS1. The predicted 415-amino acid protein shares 82% identity with its mouse homolog, Sps1, and contains the 7 conserved domains and DDxxD motifs typical of trans-prenyl diphosphate synthases.

2022年5月3日 · Patients with higher PDSS1 expression had lower CD8+ T cells in HCC tissue, and PDSS1 deteriorates T cell exhaustion by promoting T cell surface inhibitory receptors' secretion and immunosuppressive cell proliferation. Furthermore, PDSS1 was positively correlated with the WNT, TGFβ, VEGF, and other signaling pathways in HCC.