PECBA provides for an expedited bargaining process for employer proposals to change certain employment relations during the term of a collective bargaining contract (ORS 243.698). Under this process, an employer must give the union notice of its intent to change a condition that imposes a bargaining obligation.

2023年12月2日 · PEBCA ACADEMY RAWALAKOT Awareness Programme was Conducted in PEBCA Academy regarding The disease Thelesemia.Ahmed Asif Lead this Seminar... VIEW MORE. VIEW MORE. VIEW MORE. VIEW MORE. PEBCA ACADEMY RAWALAKOT . VIEW MORE. VIEW MORE. VIEW MORE. VIEW MORE. CONTACT; Call:0348-1282514; Whatsapp:0348-1282514;

2019年1月10日 · Efficient treatment of patient-derived basal-like breast cancer xenograft with NPs. PEBCA NPs with cabazitaxel gave complete remission of 6 out of 8 tumors. NPs induced higher infiltration in tumors of anti- than pro-tumorigenic macrophages. Infiltration of pro-tumorigenic macrophages strongly reduced by drug-containing NPs.

2022年2月19日 · The detection of biomedical organic nanocarriers in cells and tissues is still an experimental challenge. Here we developed an imaging strategy for the label-free detection of poly (ethylbutyl cyanoacrylate) (PEBCA) particles.

2024年2月1日 · Polyethylene glycol (PEG) conjugation (PEGylation) is a well-established strategy to improve the pharmacokinetic and biocompatibility properties of a wide variety of nanomedicines and therapeutic peptides and proteins. This broad use makes PEG an attractive ‘allround’ candidate marker for the biodistribution of such PEGylated compounds.

2024年3月26日 · We report for the first time, comparative efficacy of PEBCA and PEHCA NP variants in triple negative breast cancer models and show that CBZ-loaded PEBCA NPs exhibit a combined effect on tumor cells and on the tumor associated myeloid compartment, which may boost the anti-tumor response.

本文介绍了环丙沙星负载的聚乙基丁基氰基丙烯酸酯（PEBCA）纳米粒子的制备的优化。 环丙沙星与纳米颗粒的缔合是通过乳液聚合进行的，但只有在聚合介质中存在丙酮的情况下，才能成功捕获。 该制备过程导致稳定的环丙沙星纳米颗粒悬浮液，其平均大小值是不存在药物时获得的平均大小值的两倍，缔合效率为82％。 此外，环丙沙星纳米颗粒的分子量值与未负载的纳米颗粒相比显示出降低的趋势。 发现在含有酯酶的培养基中从胶体载体释放的药物非常缓慢（48小时后最大 …

Here we developed an imaging strategy for the label-free detection of poly (ethylbutyl cyanoacrylate) (PEBCA) particles. Experiments were carried out with phagocytic NR8383 macrophages exposed to non-toxic and non-activating concentrations of fluorescent (PEBCA NR668 and PEBCA NR668/IR), non-fluorescent (PEBCA), and cabazitaxel-loaded PEBCA ...

2024年1月1日 · 本研究旨在比较两种聚合物纳米粒子（PEBCA和PEHCA）在三阴性乳腺癌模型中的疗效，并测试叶酸结合是否会改善它们的效果。 研究人员将卡巴他赛（CBZ）包载在这些纳米粒子中，并在体内进行了药物分布和疗效研究。 结果表明，与自由药物和PEHCA纳米粒子相比，药物包载的PEBCA变体具有更好的疗效。 此外，研究人员还分析了肿瘤相关免疫细胞的种群，发现药物包载的PEBCA变体影响了髓样细胞，特别是巨噬细胞，促进了炎性、免疫激活的肿瘤微 …

This paper describes the optimization of the preparation of ciprofloxacin-loaded polyethylbutylcyanoacrylate (PEBCA) nanoparticles. The association of ciprofloxacin with nanoparticles was performed by emulsion polymerization, but successful entrapment was only obtained in the presence of acetone in the polymerization medium.