2024年12月25日 · PEBP1 (Phosphatidylethanolamine Binding Protein 1) is a Protein Coding gene. Diseases associated with PEBP1 include Merkel Cell Carcinoma and Parotid Gland Adenoid Cystic Carcinoma. Among its related pathways are Signaling downstream of RAS mutants and MAPK family signaling cascades.

In this study, we identified a new putative LIR motif in PEBP1/RKIP (phosphatidylethanolamine binding protein 1) that was originally isolated as a PE-binding protein and also a cellular inhibitor of MAPK/ERK signaling.

PEBP1, a scaffold protein inhibitor of protein kinase cascades, complexes with two 15LO isoforms, 15LO1 and 15LO2, and changes their substrate competence to generate hydroperoxy-phosphatidylethanolamines (PE).

2017年10月19日 · We demonstrated the importance of PEBP1-dependent regulatory mechanisms of ferroptotic death in airway epithelial cells in asthma, kidney epithelial cells in renal failure, and cortical and hippocampal neurons in brain trauma.

族中的pebp1 在细胞信号转导中扮演了重要角色， 且在肿瘤学领域也具有很好的临床研究价值。本文 就pebp1 的信号调节机制和生物学功能研究进展 做一回顾，为描述方便，文中一概用pebp 表示。 1 pebp的结构特征和组织分布 人pebp 基因位于染色体12q24.23，编码187

Phosphatidylethanolamine-binding protein 1 is a protein that in humans is encoded by the PEBP1 gene. [5] [6]

The small scaffolding protein PEBP1 regulates ferroptotic cell death by binding with lipoxygenases and allowing them to generate lipid peroxides.

该基因编码磷脂酰乙醇胺结合蛋白家族的成员，并已显示可调节多种信号通路，包括 MAP 激酶 (MAPK) 、NF-kappa B 和糖原合酶激酶 3 (GSK-3) 信号通路。 编码的蛋白质可以进一步加工形成更小的裂解产物海马胆碱能神经刺激肽 (HCNP) ，它可能参与神经发育。 该基因与许多人类癌症有关，可能充当转移抑制基因。 已在基因组中鉴定出该基因的多个假基因。 [RefSeq 提供，2015 年 …

2021年2月5日 · Title: Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway. Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop.

2025年2月8日 · This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways.