This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture.

2008年12月18日 · The design, fabrication, and characterization of PEG hydrogels rely on the understanding of fundamental gelation kinetics as well as the purpose of the application. This review article will focus on different polymerization mechanisms of PEG-based hydrogels and the importance of these biocompatible hydrogels in regenerative medicine applications.

2021年7月1日 · Injectable thermosensitive hydrogels are unique as 3D cell culture scaffolds in that growth factors, cells/stem cells and signalling molecules can be gently incorporated in the gel matrix through a temperature-induced sol-gel transition. PEG-polyester hydrogels have been investigated as 3D cell culture devices [183], [184], [185].

2013年7月1日 · In this review, we focused on the gelation mechanism and the relationship between structure and mechanical properties of Tetra-PEG gel. First, we show the gelation mechanism based on the chemical reaction theory. Then, we show the elastic modulus and fracture energy of Tetra-PEG gel and compare to the theoretical predictions.

2023年4月13日 · In this domain, polyethylene glycol (PEG) has become increasingly popular as a biomedical polymer and has found clinical use. Owing to their excellent biocompatibility, facile modifiability, and high drug encapsulation rate, PEG hydrogels have shown great promise as drug delivery platforms.

2017年3月5日 · Here, we prepared a PEG hydrogel (PEGH) as SSPCM via a simple sol-gel method, and its thermal storage performances were investigated for the first time. Its reversible energy density of 154.2 J/g was obtained along with the appropriate phase transition temperature located 44.8/64.5 °C.

PEGDMs were photo-polymerized in water or growth medium (in the presence of cells) to form hydrogels. We also used a facile synthetic approach to covalently attach peptides to the hydrogels. Detailed synthesis and characterization of PEGDM oligomers were carried out.

2018年11月16日 · Tetra-PEG gels, near-ideal polymer networks prepared by cross-end-coupling of A and B tetra-functional poly (ethylene glycol) (PEG) prepolymers having complementary end groups, were first fabricated in 2008. Comparisons of the mechanical properties with those of theoretical predictions indicate negligible fractions of defects and/or entanglements.

2012年8月15日 · The elastic properties of Tetra-polyethylene glycol (PEG) gel, a four-armed PEG network gel, were studied by simulating the deformation of elastic networks containing defects that...

PEG hydrogels have been widely used for cell encapsulation and therapeutic protein delivery due to their tissue-like water content, adjustable physicochemical properties and resistance to nonspecific protein adsorption.