PEGylation (or pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated.

PEGylation technology has been applied to various therapeutic modalities including small molecules, aptamers, peptides, and proteins, leading to over 30 PEGylated drugs currently used in the clinic and many investigational PEGylated agents under clinical trials.

PEGylated systems enable higher concentrations of active components and better treatment targeting in oncology. By improving accuracy and dosage, developments in PEGylated polymer-drug conjugates also hold promise for the treatment of hemophilia and diabetes.

PEGylated-carriers has been effectively employed to treat cancer disease alone as passive targeting or in combination with the ligand such as N-acetyl-d-Glucosamine (NAG) via active targeting (Pawar et al., 2012; Pawar and Vavia, 2015).

2024年3月28日 · PEGylated saccharides can be used as materials and carriers for novel drugs. PEGylated oligonucleotides can improve solubility, resistance to nucleases, and permeability of cell membranes. PEGylated biomaterials can reduce thrombosis and reduce protein and cell …

2016年2月1日 · Plegridy® is a PEGylated form of INF beta-1a (IFN β-1a), approved for the treatment of relapsing multiple sclerosis. The non-PEGylated IFN β-1a is also marketed under the name Avonex® (IFN β-1a) for the same indication.

or PEGylated In the pegylated form of interferon, the interferon alfa molecule is linked to a polyethylene glycol molecule to ensure sustained interferon concentrations after single weekly injections.

A pegylated form of human growth hormone antagonist called pegvisomant (Somavert) is being developed for the treatment of ACROMEGALY. Patients with acromegaly experience extremely high serum ...

Since the first PEGylated drug was developed in the 1970s, PEGylation of therapeutic proteins has significantly improved the treatment of several chronic diseases, including hepatitis C, leukemia, severe combined immunodeficiency disease, rheumatoid arthritis, and Crohn disease.

2023年9月22日 · Here, we summarize the diverse types of PEGylation strategies, the key advantages of PEGylated therapeutics over their parent drugs, and the broad applications and impacts of PEGylation in clinical settings.