Although pyruvate kinase M2 (PKM2) is a glycolytic enzyme known to be involved in metabolic reprogramming and gene transcription in many immune cell types, its role in neutrophils remains poorly understood. Here, we report that PKM2 regulates ROS production and microbial killing by …

2012年3月9日 · Pyruvate kinase isoform M2 (PKM2) is a glycolysis enzyme catalyzing conversion of phosphoenolpyruvate (PEP) to pyruvate by transferring a phosphate from PEP to ADP. We report here that PKM2 localizes to the cell nucleus. The levels of …

2023年7月17日 · Although pyruvate kinase M2 (PKM2) is a glycolytic enzyme known to be involved in metabolic reprogramming and gene transcription in many immune cell types, its role in...

2019年5月28日 · PKM基因编码的丙酮酸激酶负责催化糖酵解途径的最后一步反应，即将磷酸烯醇式丙酮酸（PEP）上的磷酸根转移到ADP上，从而产生丙酮酸 （Pyruvate）和ATP。 有趣的是，编码PKM的基因可以通过对mRNA的差异性剪接选择第九个外显子或者第十个外显子而表达出PKM1和PKM2两种同工酶。 PKM1和PKM2的表达有很大差异：PKM1主要在肌肉和脑这些对能量需求旺盛的分化终末细胞中表达，而PKM2则主要在胚胎细胞、干细胞和肿瘤细胞这些对合成 …

2025年4月2日 · In these regions, PKM2 uses PEP as a phosphate group donor and functions as a protein kinase, phosphorylating histone H3 at T11.

2015年2月4日 · Pyruvate kinase isoform M2 (PKM2) converts phosphoenolpyruvate (PEP) to pyruvate and plays an important role in cancer metabolism. Here, we show that post-translational modifications and a patient-derived mutation regulate pyruvate kinase activity of PKM2 through modulating the conformation of the PKM2 tetramer.

2020年3月2日 · This review is focused on the metabolic role of pyruvate kinase M2 in normal cells vs. cancerous cells and its regulation at the transcriptional level. The review also highlights the role of PKM2 as a potential diagnostic marker and as a therapeutic target in cancer treatment.

2023年12月29日 · In this review, we will introduce the biological characteristics of PKM2 and the regulation of PKM2 expression in non-neoplastic diseases, as well as its biological roles by mediating multiple signaling pathways, and focuses on the role of PKM2 in multiple signaling pathways related to neurological diseases.

PKM2 catalyses conversion of PEP in the presence of ADP to form pyruvate and ATP, the final step of the glycolytic pathway reaction. The tetrameric form of PKM2 has a high affinity for its substrate phosphoenolpyruvate (PEP) and, therefore, PEP can be converted to pyruvate at a much faster rate.

2012年3月20日 · In its tetrameric form, pyruvate kinase M2 (PKM2) functions in glycolysis by transferring a phosphate from phosphenolpyruvate (PEP) to ADP to form pyruvate. In cancer cells, dimeric PKM2 becomes abundant, and this form lacks pyruvate kinase activity, leading to altered metabolism that may provide cancer cells a metabolic advantage.