2024年12月25日 · PEX14 (Peroxisomal Biogenesis Factor 14) is a Protein Coding gene. Diseases associated with PEX14 include Peroxisome Biogenesis Disorder 13A and Peroxisome Biogenesis Disorder 1B. Among its related pathways are Peroxisomal lipid metabolism and Protein ubiquitination.

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene. [5][6] This gene encodes an essential component of the peroxisomal import machinery.

PEX14 is the 13th PEX gene responsible for peroxisome biogenesis disorders. Thus far, only two patients with PEX14 deficiency have been reported. The novel Pex14-binding site may represent the initial tethering site of Pex5 from which the cargo-loaded receptor is further processed in a sequential manner.

2023年5月10日 · In the budding yeast Saccharomyces cerevisiae, the minimum transport machinery includes the membrane proteins Pex13 and Pex14 and the cargo-protein-binding transport receptor, Pex5. Here we show...

该基因编码过氧化物酶体输入机制的重要组成部分。 该蛋白质被整合到过氧化物酶体膜中，其 C 末端暴露于胞质溶胶，并与含有 PTS1 过氧化物酶体靶向信号的蛋白质的胞质受体相互作用。 该蛋白质还充当转录辅阻遏物，并与组蛋白脱乙酰酶相互作用。 该基因的突变会导致一种形式的齐薇格综合症。 [RefSeq 提供，2008 年 7 月] This gene encodes an essential component of the peroxisomal import machinery.

Our data confirm that Pex14 is the sole peroxin that has a unique dual function in two apparent opposite processes, namely peroxisome formation and selective degradation.

2024年7月1日 · PEX14 is an essential peroxin responsible for peroxisome biogenesis. In this study, we identified the human PEX14 homolog in the brown planthopper, Nilaparvata lugens (Hemiptera: Delphacidae). N. lugens PEX14 (NlPEX14) showed significant topological similarity to its human counterpart.

2021年4月16日 · The PEX5 NTD harbors multiple WF peptide motifs (WxxxF/Y or related motifs) that are recognized by a small globular domain in the NTD of the membrane-associated protein PEX14. How the PEX5 or PEX14 NTDs bind to the peroxisomal membrane and how the interaction between the two proteins is modulated at the membrane is unknown.

Pex13 and Pex14 are key components of the peroxisomal docking complex in yeasts and mammals. In the present work, we functionally characterized the homologues of Pex13 and Pex14 (Mopex13 and Mopex14) in the rice blast fungus Magnaporthe oryzae.

Orthologous to human PEX14 (peroxisomal biogenesis factor 14). [provided by Alliance of Genome Resources, Apr 2022]