EPA announced the release of the IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts (Public Comment and External Review Draft) for a 60-day public comment period and external peer review. The deadline for comments is June 9, 2023.

Perfluorodecanoic acid (PFDA) is a fluorosurfactant and has been used in industry. [2] PFDA is a member of the group of polyfluoroalkyl substances (PFAS), more specific is it also a perfluoroalkyl acid (PFAA). PFAS, like PFDA, are man-made and are not naturally occurring in nature.

Perfluorodecanoic acid (PFDA) is a perfluoroalkyl acid (PFAA). PFAAs have been frequently detected in both the environment and in plants fish and animals. It is a breakdown product of stain- and grease-proof coatings on food packaging, couches, carpets. Like many PFAAs, it is persistent and bioaccumulative. PFAAs are thought to be endocrine ...

Epidemiological studies have revealed associations between exposure to specific PFAS and a variety of health effects, including altered immune and thyroid function, liver disease, lipid and insulin dysregulation, kidney disease, adverse reproductive and …

2024年7月22日 · EPA has finalized the IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts. This assessment addresses the potential cancer and noncancer human health effects from exposure to PFDA and related salts. EPA’s program and regional offices may use this assessment to inform decisions to protect human health.

Exposure to PFAS, some of which have been classified as carcinogenic and/or as endocrine disruptors, has been linked to cancers such as kidney, prostate and testicular cancer, ulcerative colitis, thyroid disease, suboptimal antibody response / decreased immunity, decreased fertility, hypertensive disorders in pregnancy, reduced infant and fetal ...

2024年7月16日 · Perfluorodecanoic Acid (PFDA) and its related salts are members of the group of per and polyfluoroalkyl substances (PFAS). PFAS are not naturally occurring in the environment; they are man-made compounds that have been used widely over the past several decades in consumer products and industrial applications because of their resistance to heat ...

2025年3月15日 · Extensive use of per- and polyfluoroalkyl substances (PFAS) has resulted in their ubiquitous presence in human blood. PFAS exposures have been associated with multiple adverse human health effects. Biomonitoring studies have focused on long-chain PFASs, but these are being replaced by short-chain PFASs or with alternate PFAS chemistries (or replacement chemistries such as GenX), resulting in ...

Perfluorodecanoic acid (PFDA, CASRN 335-76-2), 1 and its related salts are members of the group per- and polyfluoroalkyl substances (PFAS). This Toxicological Review applies to PFDA as well as salts (including nonmetal or alkali metal salts) of PFDA that would be expected to fully dissociate in aqueous solutions of pH ranging from 4 to 9 (e.g ...

2025年1月3日 · The nine PFAS were automatically added for Reporting Year 2025 due to EPA having finalized a toxicity value during 2024 and whose identity is not claimed as confidential business information. These nine PFAS are: Ammonium perfluorodecanoate (PFDA NH4) (3108-42-7) Sodium perfluorodecanoate (PFDA-Na) (3830-45-3)