2024年12月25日 · PFKFB1 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 1) is a Protein Coding gene. Diseases associated with PFKFB1 include Hepatocellular Carcinoma and Autism Spectrum Disorder. Among its related pathways are Glycolysis (REACTOME) and Integration of energy metabolism.

Results describe structural differences between two isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from liver and testis. This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes.

该基因编码双功能 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase 酶家族的成员。 该酶形成同型二聚体，使用独立的催化结构域催化 2,6-二磷酸果糖的合成和降解。 2,6-二磷酸果糖是糖酵解途径的激活剂和糖异生途径的抑制剂。 因此，通过这种酶的活性调节果糖 2,6-二磷酸水平被认为可以调节葡萄糖稳态。 已发现该基因的多个选择性剪接转录物变体。 [RefSeq 提供，2012 年 11 月] This gene encodes a member of the family of bifunctional 6-phosphofructo-2 …

2025年2月20日 · Results describe structural differences between two isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from liver and testis. Enables several functions, including 6-phosphofructo-2-kinase activity; anion binding activity; and fructose-2,6-bisphosphate 2-phosphatase activity.

PFKFB1 encodes the isoenzyme identified in fetal tissue and the liver; PFKFB2 encodes a protein expressed mainly in the heart and kidney; the product of PFKFB3 occurs in adipose tissue, the brain, and frequently in cancer cells; and PFKFB4 is almost exclusively significantly expressed in testes and tumor cells .

2024年3月5日 · Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

而PFKFB1、PFKFB2和PFKFB4的表达与结直肠癌的肿瘤大小、临床分期、淋巴结转移及预后等无显著相关性 (P > 0.05)。 结论 PFKFB家族在结直肠癌中高表达，且结直肠癌患者中PFKFB3高表达者比低表达者预后差，并且其作用同HIF1-α的表达密切相关。 [Abstract] Objective To investigate the expression level...

2013年10月1日 · Pfkfb (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) enzymes are bi-functional enzymes encoded by four different genes (pfkfb1, pfkfb2, pfkfb3, pfkfb4) in vertebrates. They are involved in the regulation of glycolysis: they catalyze the synthesis and the degradation of F-2,6-BP (fructose-2,6-bisphosphate), the most potent allosteric ...

PFKFB1 protein orchestrates the synthesis and degradation of fructose 2,6-bisphosphate, regulating cellular energy metabolism. Serving as a key enzyme, PFKFB1 modulates fructose 2,6-bisphosphate levels, impacting glycolysis and gluconeogenesis. Its dual role in both synthesis and breakdown is crucial for maintaining cellular energy homeostasis ...

这个酶形成一种催化合成和降解果糖-2,6-二磷酸酸使用独立催化结构域的同二聚体。 果糖-2,6-二磷酸酸是糖酵解途径的激活剂和糖异生途径的抑制剂。 因此，通过这个酶的活性调节果糖-2,6-二磷酸酸的水平被认为可以调节葡萄糖的稳态。 已经发现了这个基因的多种可变剪接转录变异体。 [由RefSeq，2012年11月提供] Dir./Indir. The DNA sequence of the human X chromosome. Complete sequencing and characterization of 21,243 full-length human cDNAs.