低氧诱导因子(hypoxia-inducible factor, HIF)是体内参与细胞低氧应答的主要转录因子， 而氧依赖性的脯氨酸羟化酶(prolyl hydroxylase, PHD)是HIF降解反应的限速酶，可羟基化HIF的脯氨酸 …
科普 | 低氧诱导因子（hypoxia-inducible factor, HIF）与肾病治 …
2020年4月30日 · 活性低氧诱导因子脯氨酰羟化酶（hif-phd）抑制剂，已开发的适应证为肾性贫血。 全球首款HIF-PHD抑制剂获批上市。 HIF-PHD在HIF的降解中起关键作用。
Role and regulation of prolyl hydroxylase domain proteins
2008年2月15日 · Oxygen-dependent hydroxylation of hypoxia-inducible factor (HIF)- α subunits by prolyl hydroxylase domain (PHD) proteins signals their polyubiquitination and proteasomal...
HIF-1α蛋白质基因与脯氨酰羟化酶，在氧气感应调节机制方面，它 …
PHD发现了四种，即PHD1-3以及PHD-TM (PHD4)， 但PHD2在HIF-1α的分解中起主要作用。 因为依赖氧气，所以氧气不足——氧气浓度不断降低的时候，HIF-1α的泛素化就会减少，于 …
脯氨酸羟化酶研究进展 - tougao120.com
脯氨酸羟化酶(prolyl hydroxylase，PHD)是缺氧诱导因子(hypoxia inducible factor，HIF)通路的重要调节因子之一。 在氧气受限的情况下，PHD的活性受到抑制，通过各种机理调节细胞内的 …
Hypoxia-inducible factor–prolyl hydroxylase inhibitors in the …
The hypoxia-inducible factor (HIF)–prolyl hydroxylase domain (PHD) pathway regulates cellular responses to hypoxia and is involved in multiple diseases, including anemia, polycythemia, …
Inflammation and Hypoxia: HIF and PHD Isoform Selectivity
2019年1月1日 · Cells sense and respond to hypoxia through the activity of the transcription factor HIF (hypoxia-inducible factor) and its regulatory hydroxylases, the prolyl hydroxylase domain …
Possible Role of PHD Inhibitors as Hypoxia-Mimicking Agents in …
2018年12月10日 · Hypoxia-inducible factors (HIFs) are key transcription heterodimers consisting of regulatory α-subunits (HIF-1α, HIF-2α, HIF-3α) and a constitutive β-subunit (HIF-β). …
PHD2: from hypoxia regulation to disease progression - PMC
HIF prolyl hydroxylase domain-2 (PHD2) has long been recognized as the major regulator of this response, controlling a myriad of outcomes that range from cell death to proliferation. …
HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for ...
In this review, I discuss the process of molecular cloning of HIF and HIF-PH, which explains hypoxia-induced EPO expression; the development of HIF-PH inhibitors that artificially or …