The histone reader PHF7 cooperates with the SWI/SNF complex at …
2021年5月3日 · We undertook a screen of mammalian gene regulatory factors to discover novel regulators of cardiac reprogramming in adult fibroblasts and identified the histone reader PHF7 …
PHF7 directs cardiac reprogramming - Nature Cell Biology
2021年5月3日 · A new study now reports that the histone reader PHF7 enhances cardiac reprogramming via recruiting the chromatin remodelling SWI/SNF complex and key …
Loss of histone reader Phf7 leads to immune pathways activation …
2023年11月17日 · Given that Phf7 functions as a histone code reader that binds methylated histone H3 (H3K4me2/me3) and controls gene expression programs, we attempted to …
The histone reader PHF7 cooperates with the SWI/SNF complex at …
We undertook a screen of mammalian gene regulatory factors to discover novel regulators of cardiac reprogramming in adult fibroblasts and identified the histone reader PHF7 as the most …
Mending broken hearts with the help of epigenetic remodellers
2021年5月6日 · Now in Nature Cell Biology, Olson and colleagues report the identification of the histone reader PHF7 as a strong activator of the reprogramming of adult cardiac fibroblasts to …
Abstract 18042: Induction of Cardiac Reprogramming Following …
2023年11月6日 · In this manuscript, we describe the ability of PHF7 to activate adult reprogramming in vitro in absence of canonical reprogramming factors, with PHF7, MEF2C, …
PHF7 is a novel histone H2A E3 ligase prior to histone-to ... - PubMed
2019年7月10日 · PHF7 deletion results in male infertility due to aberrant histone retention and impaired protamine replacement in elongated spermatids. Mechanistically, PHF7 can …
生化细胞所揭示PHF7作为一个新的泛素连接酶参与小鼠精子变形 …
科研人员通过qPCR定量和免疫荧光定位分析发现，Phf7特异性地表达在小鼠睾丸单倍体生殖细胞中，暗示对精子变形可能具有重要作用。 通过CRISPR/Cas9技术产生的 Phf7 基因敲除小鼠 …
Molecular basis for PHF7-mediated ubiquitination of histone H3
2023年12月26日 · Plant homeodomain (PHD) finger protein 7 (PHF7) is a RING-type E3 ubiquitin ligase responsible for histone ubiquitination. PHF7 comprises three zinc finger domains: an …
The histone reader PHF7 cooperates with the SWI/SNF complex at …
Mechanistically, PHF7 localizes to cardiac super enhancers in fibroblasts, and through cooperation with the SWI/SNF complex, it increases chromatin accessibility and transcription …