PhKv is a peptide isolated from the venom of the armed spider Phoneutria nigriventer. It has an antiarrythmogenic activity that involves the enhanced release of acetylcholine. The aim of this study was to investigate whether PhKv had an antinociceptive action in mice. Methods: Male albino Swiss mice (25-35g) were used in this study. The PhKv ...

2017年10月1日 · PhKv, a peptide from P. nigriventer spider venom, does not affect thermal or mechanical sensitivity in mice. PhKv caused antinociception in the chronic constriction injury model and after intraplantar injection of capsaicin. Pretreatment of mice with atropine or mecamylamine inhibited neostigmine and PhKv-induced antinociception.

2011年2月1日 · In this study, we evaluated the effects of PhKv, a 4584 Da peptide isolated from the spider Phoneutria nigriventer venom, in the isolated rat heart and in isolated ventricular myocytes. Ventricular arrhythmias were induced by occlusion of the left anterior descending coronary artery for 15 min followed by 30 min of reperfusion.

2025年1月9日 · This study explores the therapeutic potential of PhKv toxin, derived from the Brazilian wandering spider Phoneutria nigriventer, as an acetylcholinesterase inhibitor, aiming to prolong acetylcholine presence in the synaptic cleft of murine subjects.

In this study, we evaluated the effects of PhKv, a 4584 Da peptide isolated from the spider Phoneutria nigriventer venom, in the isolated rat heart and in isolated ventricular myocytes. Ventricular arrhythmias were induced by occlusion of the left anterior descending coronary artery for 15 min follo …

PhKv 是从武装蜘蛛的毒液中分离出来的肽黑风鳅。 它具有抗心律失常活性，涉及增强乙酰胆碱的释放。 本研究的目的是调查 PhKv 是否对小鼠具有镇痛作用。

This study explores the therapeutic potential of PhKv toxin, derived from the Brazilian wandering spider Phoneutria nigriventer, as an acetylcholinesterase inhibitor, aiming to prolong acetylcholine presence in the synaptic cleft of murine subjects.

The Phoneutria nigriventer peptide PhKv has shown a remarkable ability to rescue long-term memory in a mouse model of Alzheimer’s disease, due to its selective modulation of A-type transient outward K+ currents .

Conclusion: PhKv shows promise in memory improvement, warranting in-depth investigations into its mechanisms. Ongoing research explores the molecular aspects of PhKv’s action on acetylcholinesterase. Our study suggests PhKv’s therapeutic relevance in addressing cognitive deficits associated with acetylcholine dysregulation.

Spider venom is a rich cocktail of neuroactive compounds designed to prey capture and defense against predators that act on neuronal membrane proteins, in particular, acetylcholinesterases (AChE) that regulate synaptic transmission through acetylcholine (ACh) hydrolysis - an excitatory neurotransmitter - and beta-secretases (BACE) that primarily...