2016年3月21日 · Contrary to the accepted model of microbial membrane disruption by PHMB, we observed cell entry into a range of bacterial species and treated bacteria displayed cell division arrest and...

2025年3月14日 · Explore how PHMB antimicrobial interacts at the cellular level, from membrane disruption to nucleic acid binding, and methods for studying its effects. Polyhexamethylene biguanide (PHMB) is a broad-spectrum antimicrobial widely used in medical, industrial, and consumer applications.

2024年3月5日 · Poly (hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride (PHMB) is a biocide with a broad spectrum of antibacterial activity. Its use as a disinfectant and preservative in consumer products results in human exposure to PHMB.

Aiming at the improved management of infected wounds, a variety of wound dressings that incorporate antimicrobials (AMDs), namely polyhexanide (poly (hexamethylene biguanide); PHMB), have been introduced in the wound-care market.

2016年3月21日 · Here we examined how the widely used antimicrobial polyhexamethylene biguanide (PHMB) kills bacteria selectively over host cells. Contrary to the accepted model of microbial membrane disruption by PHMB, we observed cell entry into a range of bacterial species, and treated bacteria displayed cell division arrest and chromosome condensation ...

2020年5月11日 · Polyhexamethylene biguanide (PHMB) is a cationic polymer with antimicrobial and antiviral properties. It has been commonly accepted that the antimicrobial activity is due to the ability of PHMB to perforate the bacterial phospholipid membrane leading ultimately to its death.

2011年4月25日 · We therefore investigated the possibility of decreasing the cytotoxic potency of PHMB on mammalian cells while maintaining its antimicrobial efficacy by using liposomes or oil-in-water (o/w) emulsions containing almost entirely of egg yolk phosphatidylcholine forming membranous structures.

2015年5月1日 · Polyhexamethylenebiguanide hydrochloride (PHMB), a low molecular weight polymer related to chlorohexidine (CHX), is a well-known antibacterial agent. In this study, polylactide (PLA) nanofibers loaded with PHMB were produced by electrospinning to obtain 3D biodegradable scaffolds with antibacterial properties.

在这里，我们检查了广泛使用的抗菌剂聚六亚甲基双胍（phmb）如何选择性地杀死宿主细胞上的细菌。 与公认的PHMB破坏微生物膜的模型相反，我们观察到细胞进入了一系列细菌物种，处理过的细菌表现出细胞分裂停滞和染色体浓缩，表明DNA结合是一种替代的抗菌 ...

2023年2月16日 · Polyhexamethylene biguanide (PHMB) is a cationic antimicrobial polymer with bactericidal, parasiticidal and fungicidal activities. The antifungal mechanism of action...