2013年12月1日 · This paper presents a rapid, simple and stability-indicating method based on HPLC–DAD that was developed for the separation and quantification of PHMB in liquid and gel-like pharmaceutical dosage forms without tedious sample preparation for the first time.

Using SIELC’s newly introduced BIST™ method, Polyhexanide (polyhexamethylene biguanide, PHMB) can be retained on a positively-charged anion-exchange BIST™ B+ column.

2019年12月1日 · In this work an efficient, sensitive, and high-resolution separation protocol was developed to perform quantitative measurements (sub-mg L−1) of alexidine dihydrochloride (ADH) and polyhexamethylene biguanide (PHMB) in commercial multipurpose contact lens solutions (MPS).

2013年12月1日 · A rapid and simple method for the determination of polyhexamethylene biguanide (polyhexanide, PHMB) in liquid and gel-like pharmaceutical formulations by means of high performance liquid...

Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. We estimated that limit of detection is about 2 ppm for this compounds with this method. The peak of polyhexanide fractionated on several peaks due to difference in length of the polymer components.

2009年12月15日 · The objective of this study was to establish a reasonably simple and reliable method to measure very low concentrations of polyhexamethylene biguanide (PHMB) in multipurpose contact lens solutions (MPSs). By using a weak cation exchange solid phase extraction cartridge to extract the PHMB from MPS, …

A rapid and simple method for the determination of polyhexamethylene biguanide (polyhexanide, PHMB) in liquid and gel-like pharmaceutical formulations by means of high performance liquid chromatography coupled to diode-array detection (HPLC-DAD) was developed. Best separation was achieved using a cy …

2009年8月31日 · Polyhexamethylene biguanide hydrochloride (PHMB.HCL) has been utilized as a new antimicrobial providing reliable preservation in multipurpose solution (MPS) for hydrophilic contact lenses 1,2. It is a polymeric compound with low skin irritancy, low eye toxicity, fast speed of kill, stable and effective over a wide pH range.

HPLC-DAD analysis allowed the identification and quantification of phenolic acids in the methanol extracts. Results of the study revealed that the studied Salvia species are pa...

2007年2月15日 · A time-consuming and expensive high-performance liquid chromatographic (HPLC) analysis can be used for samples with high levels of quaternary ammonium based algaecides or surfactants. The proposed nickel–nioxime detection method achieves comparable PHMB results to HPLC in about 5 min and is a very economical and …