2024年12月25日 · PIGT (Phosphatidylinositol Glycan Anchor Biosynthesis Class T) is a Protein Coding gene. Diseases associated with PIGT include Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 3 and Paroxysmal Nocturnal Hemoglobinuria 2.

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene. [5][6][7] This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface.

The PIGT gene provides instructions for making a protein called GPI transamidase component PIG-T (shortened to PIG-T protein). This protein is important for the attachment of certain proteins to the cell surface.

2024年1月2日 · PIGT is a subunit of the glycosylphosphatidylinositol transamidase which involves in tumorigenesis and invasiveness. m6A modification of mRNA has been linked to cell proliferation, tumor progression and other biological events. However, how PIGT is regulated and what is the function of PIGT in bladder cancer remains to be elucidated.

2019年4月12日 · PIGT (MIM 610272) encodes phosphatidylinositol-glycan biosynthesis class T, which is a subunit of the heteropentameric GPI transamidase complex that facilitates the attachment of GPI anchors to...

The PIGT gene encodes phosphatidylinositol-glycan biosynthesis class T, a subunit of a heteropentameric transamidase complex that catalyzes the attachment of proteins to glycosylphosphatidylinositol (GPI), which functions as a plasma membrane anchor for extracellular proteins (summary by Ohishi et al., 2001 and Kvarnung et al., 2013).

PIGT-CDG is a very rare inherited condition that affects multiple parts of the body and causes multiple congenital anomalies. Affected individuals typically develop signs and symptoms of the condition during infancy.

PIGT encodes phosphatidylinositol-glycan biosynthesis class T, a subunit of the heteropentameric GPI transamidase complex that facilitates the attachment of GPI anchors to proteins .

Our results expand the clinical spectrum of PIGT-CDG, verify the pathogenicity of a novel mutation, and underline the importance of using flow cytometry and molecular methods for diagnosis in GPI anchor disorders. 2.

2025年2月9日 · Germline mutation and a somatic mutation in PIGT is associated with paroxysmal nocturnal hemoglobinuria. This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface.