Dec 25, 2024 · PLAU (Plasminogen Activator, Urokinase) is a Protein Coding gene. Diseases associated with PLAU include Quebec Platelet Disorder and Alzheimer Disease, Familial, 1. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Innate Immune System.

Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. The human urokinase protein was discovered, but not named, by McFarlane and Pilling in 1947. [5] .

PLAU is a promising new candidate gene for late-onset Alzheimer's disease, with allele C (P141) being a recessive risk allele or allele T (L141) conferring protection. u-PA down-regulation by RNAi technology decreases the invasive capability of hepatocellular carcinoma cells

Feb 11, 2021 · The urokinase-type plasminogen activator (PLAU) system mediates cell proliferation, migration, adhesion, and other functions through the proteolytic system, intracellular signal...

Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4. Belongs to the peptidase S1 family. Expressed in …

El PLAU contiene los documentos en formato PDF de los instrumentos urbanísticos y de ordenación del territorio de Castilla y León. Acceda al listado de planeamiento vigente de un municipio, seleccionando primero la provincia en el menú …

Mar 7, 2022 · These findings, for the first time, indicate that AQR/PLAU is a critical signaling axis in the modulation of endothelial cell senescence, revealing a novel link between hyperglycemia and vascular dysfunction.