2024年12月25日 · PLIN1 (Perilipin 1) is a Protein Coding gene. Diseases associated with PLIN1 include Lipodystrophy, Familial Partial, Type 4 and Lipodystrophy, Congenital Generalized, Type 1. Among its related pathways are Transcriptional regulation of white adipocyte differentiation and Triglyceride metabolism.

Perilipin, also known as lipid droplet-associated protein, perilipin 1, or PLIN, is a protein that, in humans, is encoded by the PLIN gene. [5] . The perilipins are a family of proteins that associate with the surface of lipid droplets. Phosphorylation of perilipin is essential for the mobilization of fats in adipose tissue. [6]

编码的蛋白质是脂肪细胞中主要的 cAMP 依赖性蛋白激酶底物，当未磷酸化时，可能在抑制脂肪分解中发挥作用。 已发现该基因的 5' UTR 不同但编码相同蛋白质的选择性剪接转录物变体。 [RefSeq 提供，2009 年 2 月] The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive Lipase.

2017年11月8日 · Perilipin 1 (PLIN1) is a key regulator of lipolysis in human adipocytes, where it is abundantly expressed as a phosphoprotein associated with the adipocyte lipid droplet 1.

本文对plin1 的命名、结构、表达调控、功能以及与相关疾病的关系进行 综述，着重总结PLIN1 发挥功能的分子机制，为PLIN1 的深入研究提供参考。 关键词：PLIN1；脂解；脂滴融合；疾病

PLIN1 gene is epigenetically regulated and promoter methylation is inversely correlated with basal lipolysis in obese women. OPA1 mediates adrenergic control of lipolysis in human adipocytes by regulating phosphorylation of perilipin 1.

2018年9月7日 · Perilipin 1 (Plin1), one of the major lipid droplet-binding proteins, is highly expressed in adipocytes. In mice, Plin1 deficiency impairs peripheral insulin sensitivity, accompanied with reduced fat mass. However, the mechanisms underlying insulin resistance in lean Plin1 knockout (Plin1-/-) mice are largely unknown.

2013年3月12日 · Here, we identify Perilipin1 (Plin1), another adipocyte-specific lipid droplet-associated protein, as an Fsp27 activator. Plin1 interacts with the CIDE-N domain of Fsp27 and markedly increases...

2025年2月9日 · Title: Lipid Droplet Protein PLIN1 Regulates Inflammatory Polarity in Human Macrophages and is Involved in Atherosclerotic Plaque Development by Promoting Stable Lipid Storage.

摘要：plin-1编码的PLIN1（Perilipin1）脂滴包被蛋白是脂滴表面含量最丰富的蛋白,它参与脂滴的形 成、甘油三酯的储存和脂肪分解。PLIN1对脂质代谢具有双向调节作用，与脂质代谢相关疾病联系紧密，