We report that PLZF (promyelocytic leukemia zinc finger; Zbtb16), a member of the BTB/POZ-ZF family of transcription factors which includes the CD4 lineage-specific c-Krox (Th-POK, Zbtb7b), is exquisitely specific to CD1d-restricted NKT cells and human MR1-specific MAIT cells.

2016年6月20日 · Using biotinylation-based ChIP-seq and microarray analysis of both natural killer T (NKT) cells and PLZF-transgenic thymocytes, we identified several layers of regulation of the innate-like NKT effector program.

2015年7月16日 · The transcription factor promyelocytic leukemia zinc finger (PLZF), encoded by zbtb16, is essential for the development and function of invariant 3,4 and polyclonal natural killer T (NKT) cells...

2021年8月1日 · This study investigated the role of acetylation-induced PLZF activation on NKT cell development by analyzing mice expressing a mutant form of PLZF mimicking constitutive acetylation (PLZF ON) mice. NKT populations in PLZF ON mice were reduced in proportion and numbers of cells, and the cells present were blocked at the transition from ...

我们报告说，PLZF（早幼粒细胞白血病锌指，Zbtb16）是 BTB/POZ-ZF 转录因子家族的成员，其中包括 CD4 谱系特异性 c-Krox (Th-POK)，对 CD1d 限制性转录因子具有高度特异性。

2013年2月9日 · PLZF is the master transcription factor of the NKT cell lineage. PLZF is induced during thymic development by Egr2 downstream of TCR/NFAT signaling. PLZF directs acquisition of the innate-like effector program whereas Egr2 and other TCR signals/cosignals induce cell division. In addition to the major T-bet high NKT1 subset, novel NKT ...

2012年12月21日 · 自然杀伤 (NKT) T 细胞表现出与传统 T 细胞截然不同的组织分布、表面表型和功能反应。 转录因子 PLZF 负责大多数这些特性，因为它在常规 T 细胞中的异位表达足以赋予它们 NKT 样表型。 然而，PLZF 下游的分子程序在很大程度上尚未得到探索。 在这里，我们报告说 PLZF 调节一组令人惊讶的小基因的表达，其中许多基因具有已知的免疫功能。 这包括 NKT 细胞发育计划的几个既定组成部分。 转录调节因子 Id2 的表达（先前证明是肝脏中 iNKT 细胞存活 …

Here we report that PLZF regulates the expression of a surprisingly small set of genes, many with known immune functions. This includes several established components of the NKT cell developmental program.

2011年4月1日 · Recent studies have shown that the transcriptional regulator promyelocytic leukemia zinc finger (PLZF) controls the development of essentially all of the innate-like features of invariant Natural Killer T (NKT) cells. For example, PLZF-deficient NKT cells do not acquire an ‘activated’ phenotype nor do they acquire the capacity to secrete ...

2008年9月19日 · We report that PLZF (promyelocytic leukemia zinc finger, Zbtb16), a member of the BTB/POZ-ZF family of transcription factors that includes the CD4-lineage-specific c-Krox (Th-POK), is exquisitely specific to CD1d-restricted NKT cells and human MR1-specific MAIT cells.